PMID- 21252998
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20220408
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Print)
IS  - 1471-0072 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Feb
TI  - The MRE11 complex: starting from the ends.
PG  - 90-103
LID - 10.1038/nrm3047 [doi]
AB  - The maintenance of genome stability depends on the DNA damage response (DDR), 
      which is a functional network comprising signal transduction, cell cycle 
      regulation and DNA repair. The metabolism of DNA double-strand breaks governed by 
      the DDR is important for preventing genomic alterations and sporadic cancers, and 
      hereditary defects in this response cause debilitating human pathologies, 
      including developmental defects and cancer. The MRE11 complex, composed of the 
      meiotic recombination 11 (MRE11), RAD50 and Nijmegen breakage syndrome 1 (NBS1; 
      also known as nibrin) proteins is central to the DDR, and recent insights into 
      its structure and function have been gained from in vitro structural analysis and 
      studies of animal models in which the DDR response is deficient.
FAU - Stracker, Travis H
AU  - Stracker TH
AD  - Institute for Research in Biomedicine Barcelona, C/ Baldiri Reixac 10, 08028 
      Barcelona, Spain. travis.stracker@irbbarcelona.org
FAU - Petrini, John H J
AU  - Petrini JH
LA  - eng
GR  - R37 GM059413/GM/NIGMS NIH HHS/United States
GR  - R13 CA162528/CA/NCI NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - R01 GM059413/GM/NIGMS NIH HHS/United States
GR  - R01 GM056888/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - 0 (DNA-Binding Proteins)
RN  - EC 6.5.1.- (DNA Repair Enzymes)
SB  - IM
MH  - Animals
MH  - DNA Breaks, Double-Stranded
MH  - *DNA Repair
MH  - DNA Repair Enzymes/chemistry/metabolism
MH  - DNA-Binding Proteins/*chemistry/*metabolism
MH  - Humans
MH  - Pyrococcus furiosus/chemistry/metabolism
PMC - PMC3905242
MID - NIHMS548067
EDAT- 2011/01/22 06:00
MHDA- 2011/02/17 06:00
PMCR- 2014/01/29
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
PHST- 2014/01/29 00:00 [pmc-release]
AID - nrm3047 [pii]
AID - 10.1038/nrm3047 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2011 Feb;12(2):90-103. doi: 10.1038/nrm3047.