PMID- 21270518
OWN - NLM
STAT- MEDLINE
DCOM- 20110704
LR  - 20230120
IS  - 1551-4005 (Electronic)
IS  - 1538-4101 (Print)
IS  - 1551-4005 (Linking)
VI  - 10
IP  - 3
DP  - 2011 Feb 1
TI  - Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse 
      models.
PG  - 396-405
AB  - FoxM1 transcription factor (previously called HFH-11B, Trident, FoxM1b, Win, and 
      MPP2) is expressed in actively dividing cells and critical for cell cycle 
      progression. FoxM1 expression is induced in a variety of tissues during 
      embryogenesis, and Foxm1 (-/-) mice exhibit embryonic lethal phenotype due to 
      multiple abnormalities in the liver, heart, lung and blood vessels. FoxM1 levels 
      are dramatically decreased in adult tissues, but FoxM1 expression is re-activated 
      during organ injury and numerous cancers. In this review, we discussed the role 
      of FoxM1 in different cell lineages using recent data from transgenic mouse 
      models with conditional "gain-of-function" and "loss-of-function" of FoxM1, as 
      well as tissue samples from human patients. In addition, we provided experimental 
      data showing additional sites of FoxM1 expression in the mouse embryo. Novel 
      cell-autonomous roles of FoxM1 in embryonic development, organ injury and cancer 
      formation in vivo were analyzed. Potential application of these findings for the 
      diagnosis and treatment of human diseases were discussed.
FAU - Kalin, Tanya V
AU  - Kalin TV
AD  - Division of Pulmonary Biology and Perinatal Institute of the Cincinnati 
      Children's Hospital Research Foundation, Cincinnati, OH, USA. 
      Tatiana.Kalin@cchmc.org
FAU - Ustiyan, Vladimir
AU  - Ustiyan V
FAU - Kalinichenko, Vladimir V
AU  - Kalinichenko VV
LA  - eng
GR  - R01 CA142724/CA/NCI NIH HHS/United States
GR  - R01 HL084151/HL/NHLBI NIH HHS/United States
GR  - R01 HL84151/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20110201
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxm1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Cell Cycle/*physiology
MH  - Cell Lineage
MH  - DNA Replication
MH  - Embryo, Mammalian/metabolism
MH  - Embryonic Development/genetics
MH  - Forkhead Box Protein M1
MH  - Forkhead Transcription Factors/genetics/metabolism/*physiology
MH  - Gene Silencing
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Mitosis/genetics
MH  - Neoplasms/genetics
MH  - Regeneration/genetics
PMC - PMC3115014
EDAT- 2011/01/29 06:00
MHDA- 2011/07/05 06:00
PMCR- 2012/02/01
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/07/05 06:00 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - 14709 [pii]
AID - 1538-4101-10-3-16 [pii]
AID - 10.4161/cc.10.3.14709 [doi]
PST - ppublish
SO  - Cell Cycle. 2011 Feb 1;10(3):396-405. doi: 10.4161/cc.10.3.14709. Epub 2011 Feb 
      1.