PMID- 21336274
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20231213
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Linking)
VI  - 12
IP  - 4
DP  - 2011 Apr
TI  - RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating 
      negative signals from the symbiotic microbiota.
PG  - 320-6
LID - 10.1038/ni.2002 [doi]
AB  - Lymphoid cells that express the nuclear hormone receptor RORgammat are involved in 
      containment of the large intestinal microbiota and defense against pathogens 
      through the production of interleukin 17 (IL-17) and IL-22. They include adaptive 
      IL-17-producing helper T cells (T(H)17 cells), as well as innate lymphoid cells 
      (ILCs) such as lymphoid tissue-inducer (LTi) cells and IL-22-producing NKp46+ 
      cells. Here we show that in contrast to T(H)17 cells, both types of RORgammat+ ILCs 
      constitutively produced most of the intestinal IL-22 and that the symbiotic 
      microbiota repressed this function through epithelial expression of IL-25. This 
      function was greater in the absence of adaptive immunity and was fully restored 
      and required after epithelial damage, which demonstrates a central role for 
      RORgammat+ ILCs in intestinal homeostasis. Our data identify a finely tuned 
      equilibrium among intestinal symbionts, adaptive immunity and RORgammat+ ILCs.
FAU - Sawa, Shinichiro
AU  - Sawa S
AD  - Institut Pasteur, Lymphoid Tissue Development Unit, Paris, France.
FAU - Lochner, Matthias
AU  - Lochner M
FAU - Satoh-Takayama, Naoko
AU  - Satoh-Takayama N
FAU - Dulauroy, Sophie
AU  - Dulauroy S
FAU - Berard, Marion
AU  - Berard M
FAU - Kleinschek, Melanie
AU  - Kleinschek M
FAU - Cua, Daniel
AU  - Cua D
FAU - Di Santo, James P
AU  - Di Santo JP
FAU - Eberl, Gerard
AU  - Eberl G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110220
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens, Ly)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukins)
RN  - 0 (Mydgf protein, mouse)
RN  - 0 (Natural Cytotoxicity Triggering Receptor 1)
RN  - 0 (Ncr1 protein, mouse)
RN  - 0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
SB  - IM
MH  - Adaptive Immunity/immunology
MH  - Animals
MH  - Antigens, Ly/genetics/metabolism
MH  - Female
MH  - Flow Cytometry
MH  - Homeostasis/immunology
MH  - Humans
MH  - Interleukin-17/genetics/metabolism
MH  - Interleukins/genetics/metabolism
MH  - Intestinal Mucosa/metabolism
MH  - Intestines/*immunology/microbiology
MH  - Lymphoid Tissue/cytology/*immunology/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Natural Cytotoxicity Triggering Receptor 1/genetics/metabolism
MH  - Nuclear Receptor Subfamily 1, Group F, Member 3/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Signal Transduction/*immunology
MH  - Symbiosis/immunology
MH  - Time Factors
MH  - Interleukin-22
EDAT- 2011/02/22 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/08/27 00:00 [received]
PHST- 2011/02/01 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - ni.2002 [pii]
AID - 10.1038/ni.2002 [doi]
PST - ppublish
SO  - Nat Immunol. 2011 Apr;12(4):320-6. doi: 10.1038/ni.2002. Epub 2011 Feb 20.