PMID- 21354353
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20220409
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 11
IP  - 8
DP  - 2011 Aug
TI  - Curcumin immune-mediated and anti-apoptotic mechanisms protect against renal 
      ischemia/reperfusion and distant organ induced injuries.
PG  - 992-6
LID - 10.1016/j.intimp.2011.02.015 [doi]
AB  - Renal ischemia followed by reperfusion results in kidney injury which in turn 
      produces and releases destructive inflammatory cytokines into the circulation 
      causing subsequent distant organ injury. Little data suggest the immune mechanism 
      of curcumin on protection against ischemia/reperfusion induced injury. We 
      investigated the immunomodulatory and anti-apoptotic effects of curcumin on 
      ischemia/reperfusion (I/R) injury in rats. Thirty-six rats were randomly divided 
      into three experimental groups (sham, I/R and curcumin pretreated I/R, n=12 
      each). Curcumin was administered orally to curcumin pretreated I/R group. 
      Curcumin can significantly decrease both systemic as well as blood levels of 
      cytokines (p<0.05). Treatment with curcumin also resulted in significant 
      reduction in serum and tissue level of TNF-alpha, IL-1beta, IL-12, IL-18 and INF-gamma that 
      were increased by renal I/R injury (p<0.05). Curcumin pretreatment reduce 
      pulmonary apoptotic pathway via significant inhibition of TGF-beta and caspase-3 in 
      kidney and lung tissues. Given that pulmonary apoptosis is an important 
      complication of acute renal injury, we identified curcumin protective effect 
      against distant organ I/R induced injury. Based on our results, we concluded that 
      curcumin protects the kidneys and other vital organs against I/R injury via 
      immune-mediated and the new identified anti-apoptotic mechanisms.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Awad, Azza S
AU  - Awad AS
AD  - Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar 
      University, (Girls), Nasr City, Cairo, Egypt.
FAU - El-Sharif, Amany A
AU  - El-Sharif AA
LA  - eng
PT  - Journal Article
DEP - 20110224
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 3.4.22.- (Caspase 3)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Caspase 3/metabolism
MH  - Curcumin/*pharmacology
MH  - Cytokines/antagonists & inhibitors/blood/metabolism
MH  - Immunologic Factors/*pharmacology
MH  - Kidney/*blood supply/drug effects/metabolism
MH  - Kidney Diseases/immunology/metabolism/pathology/*prevention & control
MH  - Lung/drug effects/metabolism
MH  - Lung Injury/etiology/pathology/prevention & control
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/immunology/metabolism/pathology/*prevention & control
MH  - Transforming Growth Factor beta/metabolism
EDAT- 2011/03/01 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/03/01 06:00
PHST- 2010/12/13 00:00 [received]
PHST- 2011/02/03 00:00 [revised]
PHST- 2011/02/09 00:00 [accepted]
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - S1567-5769(11)00106-8 [pii]
AID - 10.1016/j.intimp.2011.02.015 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2011 Aug;11(8):992-6. doi: 10.1016/j.intimp.2011.02.015. 
      Epub 2011 Feb 24.