PMID- 21383745 OWN - NLM STAT- MEDLINE DCOM- 20110516 LR - 20220330 IS - 1546-170X (Electronic) IS - 1078-8956 (Print) IS - 1078-8956 (Linking) VI - 17 IP - 3 DP - 2011 Mar TI - Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. PG - 320-9 LID - 10.1038/nm.2328 [doi] AB - Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use. FAU - Bissell, Mina J AU - Bissell MJ AD - Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA. mjbissell@lbl.gov FAU - Hines, William C AU - Hines WC LA - eng GR - R37 CA064786/CA/NCI NIH HHS/United States GR - U54 CA143836/CA/NCI NIH HHS/United States GR - U54CA143836/CA/NCI NIH HHS/United States GR - U54 CA126552/CA/NCI NIH HHS/United States GR - R37CA064786/CA/NCI NIH HHS/United States GR - U54 CA112970/CA/NCI NIH HHS/United States GR - U01CA143233/CA/NCI NIH HHS/United States GR - R01 CA057621/CA/NCI NIH HHS/United States GR - R01CA057621/CA/NCI NIH HHS/United States GR - U01 CA143233/CA/NCI NIH HHS/United States GR - R01 CA064786/CA/NCI NIH HHS/United States GR - U54CA126552/CA/NCI NIH HHS/United States GR - U54CA112970/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Review PL - United States TA - Nat Med JT - Nature medicine JID - 9502015 SB - IM MH - Disease Progression MH - Homeostasis MH - Humans MH - Neoplasms/*physiopathology PMC - PMC3569482 MID - NIHMS419043 COIS- COMPETING FINANCIAL INTERESTS The authors declare no competing financial interests. EDAT- 2011/03/09 06:00 MHDA- 2011/05/17 06:00 PMCR- 2013/02/11 CRDT- 2011/03/09 06:00 PHST- 2011/03/09 06:00 [entrez] PHST- 2011/03/09 06:00 [pubmed] PHST- 2011/05/17 06:00 [medline] PHST- 2013/02/11 00:00 [pmc-release] AID - nm.2328 [pii] AID - 10.1038/nm.2328 [doi] PST - ppublish SO - Nat Med. 2011 Mar;17(3):320-9. doi: 10.1038/nm.2328.