PMID- 21385708
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20151119
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 331
IP  - 6021
DP  - 2011 Mar 4
TI  - Dynamics of Dpp signaling and proliferation control.
PG  - 1154-9
LID - 10.1126/science.1200037 [doi]
AB  - Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form graded 
      concentration profiles that control patterning and growth of developing organs. 
      In the imaginal discs, proliferative growth is homogeneous in space, posing the 
      conundrum of how morphogen concentration gradients could control 
      position-independent growth. To understand the mechanism of proliferation control 
      by the Dpp gradient, we quantified Dpp concentration and signaling levels during 
      wing disc growth. Both Dpp concentration and signaling gradients scale with 
      tissue size during development. On average, cells divide when Dpp signaling 
      levels have increased by 50%. Our observations are consistent with a growth 
      control mechanism based on temporal changes of cellular morphogen signaling 
      levels. For a scaling gradient, this mechanism generates position-independent 
      growth rates.
FAU - Wartlick, O
AU  - Wartlick O
AD  - Department of Biochemistry, Faculty of Sciences, Geneva University, 30 Quai 
      Ernest-Ansermet, 1211 Geneva, Switzerland.
FAU - Mumcu, P
AU  - Mumcu P
FAU - Kicheva, A
AU  - Kicheva A
FAU - Bittig, T
AU  - Bittig T
FAU - Seum, C
AU  - Seum C
FAU - Julicher, F
AU  - Julicher F
FAU - Gonzalez-Gaitan, M
AU  - Gonzalez-Gaitan M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (dpp protein, Drosophila)
SB  - IM
CIN - Science. 2011 Mar 4;331(6021):1141-2. PMID: 21385701
CIN - Science. 2012 Jan 27;335(6067):401; author reply 401. PMID: 22282789
MH  - Animals
MH  - Cell Cycle
MH  - *Cell Proliferation
MH  - Computer Simulation
MH  - Drosophila Proteins/*metabolism
MH  - Drosophila melanogaster/cytology/genetics/*growth & development/*metabolism
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Models, Biological
MH  - Morphogenesis
MH  - Mutation
MH  - *Signal Transduction
MH  - Wings, Animal/anatomy & histology/cytology/*growth & development/*metabolism
EDAT- 2011/03/10 06:00
MHDA- 2011/03/24 06:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - 331/6021/1154 [pii]
AID - 10.1126/science.1200037 [doi]
PST - ppublish
SO  - Science. 2011 Mar 4;331(6021):1154-9. doi: 10.1126/science.1200037.