PMID- 21402747
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20220321
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 208
IP  - 3
DP  - 2011 Mar 14
TI  - The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages 
      move in.
PG  - 421-8
LID - 10.1084/jem.20110132 [doi]
AB  - Stem cell niches are defined as the cellular and molecular microenvironments that 
      regulate stem cell function together with stem cell autonomous mechanisms. This 
      includes control of the balance between quiescence, self-renewal, and 
      differentiation, as well as the engagement of specific programs in response to 
      stress. In mammals, the best understood niche is that harboring bone marrow 
      hematopoietic stem cells (HSCs). Recent studies have expanded the number of cell 
      types contributing to the HSC niche. Perivascular mesenchymal stem cells and 
      macrophages now join the previously identified sinusoidal endothelial cells, 
      sympathetic nerve fibers, and cells of the osteoblastic lineage to form similar, 
      but distinct, niches that harbor dormant and self-renewing HSCs during 
      homeostasis and mediate stem cell mobilization in response to granulocyte 
      colony-stimulating factor.
FAU - Ehninger, Armin
AU  - Ehninger A
AD  - Division of Stem Cells and Cancer, German Cancer Research Center, D-69120 
      Heidelberg, Germany.
FAU - Trumpp, Andreas
AU  - Trumpp A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
CIN - Chow et al.
CIN - Christopher et al.
MH  - Animals
MH  - Bone Marrow/*growth & development/physiology
MH  - Granulocyte Colony-Stimulating Factor/physiology
MH  - Humans
MH  - Macrophages/*physiology
MH  - Mesenchymal Stem Cells/*physiology
MH  - Monocytes/physiology
MH  - Stem Cell Niche/*cytology/physiology
PMC - PMC3058583
EDAT- 2011/03/16 06:00
MHDA- 2011/05/25 06:00
PMCR- 2011/09/14
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
PHST- 2011/09/14 00:00 [pmc-release]
AID - jem.20110132 [pii]
AID - 20110132 [pii]
AID - 10.1084/jem.20110132 [doi]
PST - ppublish
SO  - J Exp Med. 2011 Mar 14;208(3):421-8. doi: 10.1084/jem.20110132.