PMID- 21509540
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20230603
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 68
IP  - 15
DP  - 2011 Aug
TI  - Regulation of self-renewal and differentiation by the intestinal stem cell niche.
PG  - 2513-23
LID - 10.1007/s00018-011-0687-5 [doi]
AB  - The gastrointestinal epithelium is a highly organised tissue that is constantly 
      being renewed. In order to maintain homeostasis, the balance between intestinal 
      stem cell (ISC) self-renewal and differentiation must be carefully regulated. In 
      this review, we describe how the intestinal stem cell niche provides a unique 
      environment to regulate self-renewal and differentiation of ISCs. It has 
      traditionally been believed that the mesenchymal myofibroblasts play an important 
      role in the crosstalk between ISCs and the niche. However, recent evidence in 
      Drosophila and in vertebrates suggests that epithelial cells also contribute to 
      the niche. We discuss the multiple signalling pathways that are utilised to 
      regulate stemness within the niche, including members of the Wnt, BMP and 
      Hedgehog pathways, and how aberrations in these signals lead to disruption of the 
      normal crypt-villus axis. Finally, we also discuss how CDX1 and inhibition of the 
      Notch pathway are important in specifying enterocyte and goblet cell 
      differentiation respectively.
FAU - Yeung, Trevor M
AU  - Yeung TM
AD  - Division of Hematology, Department of Medicine, Stanford University School of 
      Medicine, Center for Clinical Sciences Research 1155, Stanford, CA 94305, USA.
FAU - Chia, Luis A
AU  - Chia LA
FAU - Kosinski, Cynthia M
AU  - Kosinski CM
FAU - Kuo, Calvin J
AU  - Kuo CJ
LA  - eng
GR  - 1R01DK085720/DK/NIDDK NIH HHS/United States
GR  - T32 CA009302/CA/NCI NIH HHS/United States
GR  - R01 DK085720/DK/NIDDK NIH HHS/United States
GR  - 1R01DK069989/DK/NIDDK NIH HHS/United States
GR  - U24 DK085532/DK/NIDDK NIH HHS/United States
GR  - R01 DK069989/DK/NIDDK NIH HHS/United States
GR  - U01 DK085527/DK/NIDDK NIH HHS/United States
GR  - U01 DK085532/DK/NIDDK NIH HHS/United States
GR  - 1U01DK085527/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110421
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Wnt Proteins)
SB  - IM
MH  - Animals
MH  - Bone Morphogenetic Proteins/genetics/metabolism/physiology
MH  - *Cell Differentiation/genetics/physiology
MH  - *Cell Proliferation
MH  - Hedgehog Proteins/genetics/metabolism/physiology
MH  - Humans
MH  - Intestinal Mucosa/metabolism
MH  - Intestines/*cytology/physiology
MH  - Models, Biological
MH  - Stem Cell Niche/metabolism/*physiology
MH  - Wnt Proteins/genetics/metabolism/physiology
PMC - PMC4165857
MID - NIHMS602729
EDAT- 2011/04/22 06:00
MHDA- 2011/09/10 06:00
PMCR- 2011/04/21
CRDT- 2011/04/22 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/03/18 00:00 [revised]
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
PHST- 2011/04/21 00:00 [pmc-release]
AID - 687 [pii]
AID - 10.1007/s00018-011-0687-5 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2011 Aug;68(15):2513-23. doi: 10.1007/s00018-011-0687-5. Epub 
      2011 Apr 21.