PMID- 21512136
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20220408
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 71
IP  - 12
DP  - 2011 Jun 15
TI  - LIN28B promotes colon cancer progression and metastasis.
PG  - 4260-8
LID - 10.1158/0008-5472.CAN-10-4637 [doi]
AB  - LIN28B is a homologue of LIN28 that induces pluripotency when expressed in 
      conjunction with OCT4, SOX2, and KLF4 in somatic fibroblasts. LIN28B represses 
      biogenesis of let-7 microRNAs and is implicated in both development and 
      tumorigenesis. Recently, we have determined that LIN28B overexpression occurs in 
      colon tumors. We conducted a comprehensive analysis of LIN28B protein expression 
      in human colon adenocarcinomas. We found that LIN28B overexpression correlates 
      with reduced patient survival and increased probability of tumor recurrence. To 
      elucidate tumorigenic functions of LIN28B, we constitutively expressed LIN28B in 
      colon cancer cells and evaluated tumor formation in vivo. Tumors with 
      constitutive LIN28B expression exhibit increased expression of colonic stem cell 
      markers LGR5 and PROM1, mucinous differentiation, and metastasis. Together, our 
      findings point to a function for LIN28B in promoting colon tumor pathogenesis, 
      especially metastasis.
FAU - King, Catrina E
AU  - King CE
AD  - Gastroenterology Division and Department of Medicine, University of Pennsylvania, 
      Philadelphia, Pennsylvania 19104, USA.
FAU - Cuatrecasas, Miriam
AU  - Cuatrecasas M
FAU - Castells, Antoni
AU  - Castells A
FAU - Sepulveda, Antonia R
AU  - Sepulveda AR
FAU - Lee, Ju-Seog
AU  - Lee JS
FAU - Rustgi, Anil K
AU  - Rustgi AK
LA  - eng
GR  - P30 DK050306/DK/NIDDK NIH HHS/United States
GR  - R01 DK056645/DK/NIDDK NIH HHS/United States
GR  - U01 DK085551/DK/NIDDK NIH HHS/United States
GR  - P30 CA016520/CA/NCI NIH HHS/United States
GR  - P30-DK050306/DK/NIDDK NIH HHS/United States
GR  - R01 DK056645-12/DK/NIDDK NIH HHS/United States
GR  - U01 DK085551-03/DK/NIDDK NIH HHS/United States
GR  - R01-DK056645/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110421
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Lin28A protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Cell Differentiation
MH  - Colonic Neoplasms/*etiology/mortality/pathology
MH  - Disease Progression
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Kruppel-Like Factor 4
MH  - Male
MH  - Mice
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplastic Stem Cells/physiology
MH  - RNA-Binding Proteins/*physiology
PMC - PMC3117110
MID - NIHMS292022
COIS- Conflicts of Interest The authors declare no conflict of interest.
EDAT- 2011/04/23 06:00
MHDA- 2011/08/19 06:00
PMCR- 2012/06/15
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PHST- 2012/06/15 00:00 [pmc-release]
AID - 0008-5472.CAN-10-4637 [pii]
AID - 10.1158/0008-5472.CAN-10-4637 [doi]
PST - ppublish
SO  - Cancer Res. 2011 Jun 15;71(12):4260-8. doi: 10.1158/0008-5472.CAN-10-4637. Epub 
      2011 Apr 21.