PMID- 21550344 OWN - NLM STAT- MEDLINE DCOM- 20120110 LR - 20111123 IS - 1873-3468 (Electronic) IS - 0014-5793 (Linking) VI - 585 IP - 23 DP - 2011 Dec 1 TI - How do immune cells overcome the blood-brain barrier in multiple sclerosis? PG - 3770-80 LID - 10.1016/j.febslet.2011.04.066 [doi] AB - The presence of the blood-brain barrier (BBB) restricts the movement of soluble mediators and leukocytes from the periphery to the central nervous system (CNS). Leukocyte entry into the CNS is nonetheless an early event in multiple sclerosis (MS), an inflammatory disorder of the CNS. Whether BBB dysfunction precedes immune cell infiltration or is the consequence of perivascular leukocyte accumulation remains enigmatic, but leukocyte migration modifies BBB permeability. Immune cells of MS subjects express inflammatory cytokines, reactive oxygen species (ROS) and enzymes that can facilitate their migration to the CNS by influencing BBB function, either directly or indirectly. In this review, we describe how immune cells from the peripheral blood overcome the BBB and promote CNS inflammation in MS through BBB disruption. CI - Copyright (c) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. FAU - Larochelle, Catherine AU - Larochelle C AD - Neuroimmunology Research Laboratory, Center of Excellence in Neuromics, CRCHUM, Notre-Dame Hospital, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada. FAU - Alvarez, Jorge Ivan AU - Alvarez JI FAU - Prat, Alexandre AU - Prat A LA - eng GR - MOP 14828/Canadian Institutes of Health Research/Canada GR - MOP 89885/Canadian Institutes of Health Research/Canada PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20110504 PL - England TA - FEBS Lett JT - FEBS letters JID - 0155157 RN - 0 (Reactive Oxygen Species) RN - EC 3.4.24.- (Matrix Metalloproteinases) SB - IM MH - Animals MH - Blood-Brain Barrier/*immunology/pathology MH - Cell Movement MH - Humans MH - Lymphocytes/*immunology MH - Matrix Metalloproteinases/metabolism MH - Multiple Sclerosis/enzymology/*immunology/pathology MH - Reactive Oxygen Species/metabolism EDAT- 2011/05/10 06:00 MHDA- 2012/01/11 06:00 CRDT- 2011/05/10 06:00 PHST- 2011/04/01 00:00 [received] PHST- 2011/04/26 00:00 [revised] PHST- 2011/04/27 00:00 [accepted] PHST- 2011/05/10 06:00 [entrez] PHST- 2011/05/10 06:00 [pubmed] PHST- 2012/01/11 06:00 [medline] AID - S0014-5793(11)00336-X [pii] AID - 10.1016/j.febslet.2011.04.066 [doi] PST - ppublish SO - FEBS Lett. 2011 Dec 1;585(23):3770-80. doi: 10.1016/j.febslet.2011.04.066. Epub 2011 May 4.