PMID- 21592772
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20211020
IS  - 1879-0429 (Electronic)
IS  - 0958-1669 (Print)
IS  - 0958-1669 (Linking)
VI  - 22
IP  - 6
DP  - 2011 Dec
TI  - Applications of viral nanoparticles in medicine.
PG  - 901-8
LID - 10.1016/j.copbio.2011.04.020 [doi]
AB  - Several nanoparticle platforms are currently being developed for applications in 
      medicine, including both synthetic materials and naturally occurring 
      bionanomaterials such as viral nanoparticles (VNPs) and their genome-free 
      counterparts, virus-like particles (VLPs). A broad range of genetic and chemical 
      engineering methods have been established that allow VNP/VLP formulations to 
      carry large payloads of imaging reagents or drugs. Furthermore, targeted VNPs and 
      VLPs can be generated by including peptide ligands on the particle surface. In 
      this article, we highlight state-of-the-art virus engineering principles and 
      discuss recent advances that bring potential biomedical applications a step 
      closer. Viral nanotechnology has now come of age and it will not be long before 
      these formulations assume a prominent role in the clinic.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Yildiz, Ibrahim
AU  - Yildiz I
AD  - Department of Biomedical Engineering, Case Western Reserve University, Cleveland, 
      OH 44106, USA.
FAU - Shukla, Sourabh
AU  - Shukla S
FAU - Steinmetz, Nicole F
AU  - Steinmetz NF
LA  - eng
GR  - P30 EB011317/EB/NIBIB NIH HHS/United States
GR  - R00 EB009105/EB/NIBIB NIH HHS/United States
GR  - R00 EB009105-03/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110516
PL  - England
TA  - Curr Opin Biotechnol
JT  - Current opinion in biotechnology
JID - 9100492
SB  - IM
MH  - Diagnostic Imaging
MH  - Genetic Engineering
MH  - Genetic Vectors
MH  - Molecular Imaging
MH  - Nanomedicine/*methods/*trends
MH  - Nanoparticles/*therapeutic use
MH  - Virion/genetics/*metabolism
PMC - PMC3206135
MID - NIHMS297244
EDAT- 2011/05/20 06:00
MHDA- 2012/04/20 06:00
PMCR- 2012/12/01
CRDT- 2011/05/20 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/04/21 00:00 [revised]
PHST- 2011/04/25 00:00 [accepted]
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - S0958-1669(11)00083-8 [pii]
AID - 10.1016/j.copbio.2011.04.020 [doi]
PST - ppublish
SO  - Curr Opin Biotechnol. 2011 Dec;22(6):901-8. doi: 10.1016/j.copbio.2011.04.020. 
      Epub 2011 May 16.