PMID- 21601921
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20240323
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 32
IP  - 25
DP  - 2011 Sep
TI  - Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug 
      delivery vehicles.
PG  - 5906-14
LID - 10.1016/j.biomaterials.2011.04.069 [doi]
AB  - Curcumin, a hydrophobic polyphenol, is an extract of turmeric root with 
      antioxidant, anti-inflammatory and anti-tumorigenic properties. Its lack of water 
      solubility and relatively low bioavailability set major limitations for its 
      therapeutic use. In this study, a self-assembling peptide hydrogel is 
      demonstrated to be an effective vehicle for the localized delivery of curcumin 
      over sustained periods of time. The curcumin-hydrogel is prepared in-situ where 
      curcumin encapsulation within the hydrogel network is accomplished concurrently 
      with peptide self-assembly. Physical and in vitro biological studies were used to 
      demonstrate the effectiveness of curcumin-loaded beta-hairpin hydrogels as 
      injectable agents for localized curcumin delivery. Notably, rheological 
      characterization of the curcumin-loaded hydrogel before and after shear flow have 
      indicated solid-like properties even at high curcumin payloads. In vitro 
      experiments with a medulloblastoma cell line confirm that the encapsulation of 
      the curcumin within the hydrogel does not have an adverse effect on its 
      bioactivity. Most importantly, the rate of curcumin release and its consequent 
      therapeutic efficacy can be conveniently modulated as a function of the 
      concentration of the MAX8 peptide.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Altunbas, Aysegul
AU  - Altunbas A
AD  - Department of Materials Science and Engineering, University of Delaware, Newark, 
      DE 19716, United States.
FAU - Lee, Seung J
AU  - Lee SJ
FAU - Rajasekaran, Sigrid A
AU  - Rajasekaran SA
FAU - Schneider, Joel P
AU  - Schneider JP
FAU - Pochan, Darrin J
AU  - Pochan DJ
LA  - eng
GR  - P20 RR017716/RR/NCRR NIH HHS/United States
GR  - P20 RR017716-09/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110523
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Drug Carriers)
RN  - 0 (Hydrogels)
RN  - 0 (Peptides)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Circular Dichroism
MH  - Curcumin/*administration & dosage
MH  - *Drug Carriers
MH  - *Drug Delivery Systems
MH  - *Hydrogels
MH  - Microscopy, Electron, Transmission
MH  - *Peptides
MH  - Rheology
PMC - PMC3119512
MID - NIHMS292626
EDAT- 2011/05/24 06:00
MHDA- 2011/09/29 06:00
PMCR- 2011/09/01
CRDT- 2011/05/24 06:00
PHST- 2011/04/11 00:00 [received]
PHST- 2011/04/23 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - S0142-9612(11)00491-1 [pii]
AID - 10.1016/j.biomaterials.2011.04.069 [doi]
PST - ppublish
SO  - Biomaterials. 2011 Sep;32(25):5906-14. doi: 10.1016/j.biomaterials.2011.04.069. 
      Epub 2011 May 23.