PMID- 21609825
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20240317
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 70
IP  - 4
DP  - 2011 May 26
TI  - Adult neurogenesis in the mammalian brain: significant answers and significant 
      questions.
PG  - 687-702
LID - 10.1016/j.neuron.2011.05.001 [doi]
AB  - Adult neurogenesis, a process of generating functional neurons from adult neural 
      precursors, occurs throughout life in restricted brain regions in mammals. The 
      past decade has witnessed tremendous progress in addressing questions related to 
      almost every aspect of adult neurogenesis in the mammalian brain. Here we review 
      major advances in our understanding of adult mammalian neurogenesis in the 
      dentate gyrus of the hippocampus and from the subventricular zone of the lateral 
      ventricle, the rostral migratory stream to the olfactory bulb. We highlight 
      emerging principles that have significant implications for stem cell biology, 
      developmental neurobiology, neural plasticity, and disease mechanisms. We also 
      discuss remaining questions related to adult neural stem cells and their niches, 
      underlying regulatory mechanisms, and potential functions of newborn neurons in 
      the adult brain. Building upon the recent progress and aided by new technologies, 
      the adult neurogenesis field is poised to leap forward in the next decade.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ming, Guo-Li
AU  - Ming GL
AD  - Institute for Cell Engineering, Johns Hopkins University School of Medicine, 
      Baltimore, MD 21205, USA. gming1@jhmi.edu
FAU - Song, Hongjun
AU  - Song H
LA  - eng
GR  - R01 HD069184/HD/NICHD NIH HHS/United States
GR  - R01 HD069184-01/HD/NICHD NIH HHS/United States
GR  - R01 AG024984/AG/NIA NIH HHS/United States
GR  - R33 MH087874/MH/NIMH NIH HHS/United States
GR  - NS048271/NS/NINDS NIH HHS/United States
GR  - R37 NS047344/NS/NINDS NIH HHS/United States
GR  - MH087874/MH/NIMH NIH HHS/United States
GR  - R56 NS047344/NS/NINDS NIH HHS/United States
GR  - R01 NS047344-09/NS/NINDS NIH HHS/United States
GR  - R01 NS048271/NS/NINDS NIH HHS/United States
GR  - R01 AG024984-05/AG/NIA NIH HHS/United States
GR  - R21 MH087874-02/MH/NIMH NIH HHS/United States
GR  - R01 NS048271-06/NS/NINDS NIH HHS/United States
GR  - R21 MH087874/MH/NIMH NIH HHS/United States
GR  - R01 NS047344/NS/NINDS NIH HHS/United States
GR  - AG24984/AG/NIA NIH HHS/United States
GR  - HD069184/HD/NICHD NIH HHS/United States
GR  - NS047344/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain/cytology/*physiology
MH  - Humans
MH  - Nervous System Diseases/pathology/surgery
MH  - Neural Stem Cells/cytology/*physiology/transplantation
MH  - Neurogenesis/*physiology
MH  - Neuronal Plasticity/*physiology
PMC - PMC3106107
MID - NIHMS295141
EDAT- 2011/05/26 06:00
MHDA- 2011/08/17 06:00
PMCR- 2012/05/26
CRDT- 2011/05/26 06:00
PHST- 2011/05/02 00:00 [accepted]
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
PHST- 2012/05/26 00:00 [pmc-release]
AID - S0896-6273(11)00348-5 [pii]
AID - 10.1016/j.neuron.2011.05.001 [doi]
PST - ppublish
SO  - Neuron. 2011 May 26;70(4):687-702. doi: 10.1016/j.neuron.2011.05.001.