PMID- 21609827
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20220129
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 70
IP  - 4
DP  - 2011 May 26
TI  - Neural stem cell biology in vertebrates and invertebrates: more alike than 
      different?
PG  - 719-29
LID - 10.1016/j.neuron.2011.05.016 [doi]
AB  - Many of the regulatory mechanisms controlling neural stem cell behavior are 
      proving to be conserved between organisms as diverse as worms and man. Common 
      principles are emerging with respect to the regulation of neural stem cell 
      division and the specification of distinct stem and progenitor cell types. Great 
      progress has been made in recent years in identifying the cellular mechanisms 
      underpinning these processes, thanks in large part to the cross-fertilization of 
      research on different model systems. We review here recent findings that 
      highlight hitherto unappreciated similarities in the cell and molecular biology 
      of neural stem cell self-renewal and differentiation between invertebrates and 
      vertebrates. As well as underscoring the possible conservation of stem cell 
      mechanisms across phyla, these similarities are proving to be practically useful 
      in studying neural stem cell biology in health and disease.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Brand, Andrea H
AU  - Brand AH
AD  - The Gurdon Institute and Department of Physiology, Development and Neuroscience, 
      University of Cambridge, UK. a.brand@gurdon.cam.ac.uk
FAU - Livesey, Frederick J
AU  - Livesey FJ
LA  - eng
GR  - 092096/WT_/Wellcome Trust/United Kingdom
GR  - G0800784/MRC_/Medical Research Council/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
SB  - IM
MH  - Animals
MH  - Cell Division/*physiology
MH  - Humans
MH  - Invertebrates/cytology/physiology
MH  - Neural Stem Cells/*cytology/*physiology
MH  - Neurogenesis/*physiology
MH  - Species Specificity
MH  - Vertebrates/anatomy & histology/physiology
EDAT- 2011/05/26 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/12 00:00 [accepted]
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - S0896-6273(11)00397-7 [pii]
AID - 10.1016/j.neuron.2011.05.016 [doi]
PST - ppublish
SO  - Neuron. 2011 May 26;70(4):719-29. doi: 10.1016/j.neuron.2011.05.016.