PMID- 2164567
OWN - NLM
STAT- MEDLINE
DCOM- 19900817
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 55
IP  - 2
DP  - 1990 Aug
TI  - Interferon suppresses sympathetic neuronal cell death caused by nerve growth 
      factor deprivation.
PG  - 436-45
AB  - Cultured rat sympathetic neurons die within 48 h after being deprived of nerve 
      growth factor. Addition of interferons (IFN-alpha/beta or IFN-gamma) prevented 
      the cell death in a dose-dependent manner. Upon longer periods of nerve growth 
      factor deprivation, IFNs failed to maintain survival. Thus, IFNs retarded 
      neuronal death, but did not prevent it. Ligand binding, autoradiography, and 
      cross-linking experiments demonstrated the presence of specific IFN-gamma 
      receptors on sympathetic neurons similar to those seen on other cell types. The 
      possible relationships of the death-suppressing actions of IFNs are compared to 
      the mechanisms of the antiviral or antiproliferative actions of IFNs.
FAU - Chang, J Y
AU  - Chang JY
AD  - Department of Pharmacology, Washington University School of Medicine, St. Louis, 
      Missouri 63110.
FAU - Martin, D P
AU  - Martin DP
FAU - Johnson, E M Jr
AU  - Johnson EM Jr
LA  - eng
GR  - GM07085/GM/NIGMS NIH HHS/United States
GR  - NS18072/NS/NINDS NIH HHS/United States
GR  - ST32HL07275/ST/OHS HRSA HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Interferon Type I)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Interferon)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Recombinant Proteins)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 2.7.4.3 (Adenylate Kinase)
SB  - IM
MH  - Adenylate Kinase/metabolism
MH  - Animals
MH  - Antibodies, Monoclonal/pharmacology
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Ganglia, Sympathetic/*cytology/embryology
MH  - Interferon Type I/*pharmacology
MH  - Interferon-gamma/*pharmacology
MH  - Nerve Growth Factors/immunology/*physiology
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Neurons/*cytology/metabolism
MH  - Rats
MH  - Receptors, Cell Surface/metabolism
MH  - Receptors, Immunologic/metabolism
MH  - Receptors, Interferon
MH  - Receptors, Nerve Growth Factor
MH  - Recombinant Proteins
MH  - Time Factors
EDAT- 1990/08/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
AID - 10.1111/j.1471-4159.1990.tb04155.x [doi]
PST - ppublish
SO  - J Neurochem. 1990 Aug;55(2):436-45. doi: 10.1111/j.1471-4159.1990.tb04155.x.