PMID- 21673720
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20220321
IS  - 1471-0048 (Electronic)
IS  - 1471-003X (Linking)
VI  - 12
IP  - 7
DP  - 2011 Jun 15
TI  - Repertoire of microglial and macrophage responses after spinal cord injury.
PG  - 388-99
LID - 10.1038/nrn3053 [doi]
AB  - Macrophages from the peripheral circulation and those derived from resident 
      microglia are among the main effector cells of the inflammatory response that 
      follows spinal cord trauma. There has been considerable debate in the field as to 
      whether the inflammatory response is good or bad for tissue protection and 
      repair. Recent studies on macrophage polarization in non-neural tissues have shed 
      much light on their changing functional states. In the context of this 
      literature, we discuss the activation of macrophages and microglia following 
      spinal cord injury, and their effects on repair. Harnessing their 
      anti-inflammatory properties could pave the way for new therapeutic strategies 
      for spinal cord trauma.
FAU - David, Samuel
AU  - David S
AD  - The Research Institute of the McGill University Health Center, 1650 Cedar Avenue, 
      Montreal, Quebec, Canada, H3G 1A4. sam.david@mcgill.ca
FAU - Kroner, Antje
AU  - Kroner A
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110615
PL  - England
TA  - Nat Rev Neurosci
JT  - Nature reviews. Neuroscience
JID - 100962781
SB  - IM
MH  - Animals
MH  - Cell Polarity/physiology
MH  - Humans
MH  - Inflammation/etiology/pathology
MH  - Macrophages/classification/*physiology
MH  - Microglia/*physiology
MH  - Models, Biological
MH  - Spinal Cord Injuries/complications/*pathology
EDAT- 2011/06/16 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - nrn3053 [pii]
AID - 10.1038/nrn3053 [doi]
PST - epublish
SO  - Nat Rev Neurosci. 2011 Jun 15;12(7):388-99. doi: 10.1038/nrn3053.