PMID- 21676609
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20210212
IS  - 1879-0429 (Electronic)
IS  - 0958-1669 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Aug
TI  - Polymer therapeutics as nanomedicines: new perspectives.
PG  - 492-501
LID - 10.1016/j.copbio.2011.05.507 [doi]
AB  - A growing number of polymer therapeutics have entered routine clinical use as 
      nano-sized medicines. Early products were developed as anticancer agents, but 
      treatments for a range of diseases and different routes of administration have 
      followed--recently the PEGylated-anti-TNF Fab Cimzia(R) for rheumatoid arthritis 
      and the PEG-aptamer Macugen(R) for age related macular degeneration. New polymer 
      therapeutic concepts continue to emerge with a growing number of conjugates 
      entering clinical development, for example PEGylated-aptamers and a polymer-based 
      siRNA delivery system. 'Hot' topics of the past 2 years include; emerging issues 
      relating to polymer safety, the increasing use of biodegradable polymers, design 
      of technologies for combination therapy, potential biomarkers for patient 
      individualisation of treatment and Regulatory challenges for 'follow-on/generic' 
      polymer therapeutics.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Duncan, Ruth
AU  - Duncan R
AD  - Polymer Therapeutics Lab., Centro de Investigacion Principe Felipe, Av. Autopista 
      del Saler 16 E-46012, Valencia, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110614
PL  - England
TA  - Curr Opin Biotechnol
JT  - Current opinion in biotechnology
JID - 9100492
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/therapeutic use
MH  - Clinical Trials as Topic
MH  - *Drug Design
MH  - Humans
MH  - Nanomedicine/*methods
MH  - Polymers/chemistry/*therapeutic use
EDAT- 2011/06/17 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/03/07 00:00 [received]
PHST- 2011/05/18 00:00 [revised]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - S0958-1669(11)00607-0 [pii]
AID - 10.1016/j.copbio.2011.05.507 [doi]
PST - ppublish
SO  - Curr Opin Biotechnol. 2011 Aug;22(4):492-501. doi: 10.1016/j.copbio.2011.05.507. 
      Epub 2011 Jun 14.