PMID- 21677687
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20211203
IS  - 2041-4889 (Electronic)
VI  - 2
IP  - 6
DP  - 2011 Jun 16
TI  - WW domain interactions regulate the Hippo tumor suppressor pathway.
PG  - e172
LID - 10.1038/cddis.2011.53 [doi]
AB  - The Hippo kinase pathway is emerging as a conserved signaling pathway that is 
      essential for organ growth and tumorigenesis in Drosophila and mammalians. 
      Although the signaling of the core kinases is relatively well understood, less is 
      known about the upstream inputs, downstream outputs and regulation of the whole 
      cascade. Enrichment of the Hippo pathway components with WW domains and their 
      cognate proline-rich interacting motifs provides a versatile platform for further 
      understanding the mechanisms that regulate organ growth and tumorigenesis. Here, 
      we review recently discovered mechanisms of WW domain-mediated interactions that 
      contribute to the regulation of the Hippo signaling pathway in tumorigenesis. We 
      further discuss new insights and future directions on the emerging role of such 
      regulation.
FAU - Salah, Z
AU  - Salah Z
AD  - The Lautenberg Center for General and Tumor Immunology, Department of Immunology 
      and Cancer Research-IMRIC, The Hebrew University-Hadassah Medical School, 
      Jerusalem, Israel.
FAU - Aqeilan, R I
AU  - Aqeilan RI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110616
PL  - England
TA  - Cell Death Dis
JT  - Cell death & disease
JID - 101524092
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Protein Interaction Domains and Motifs
MH  - Protein Serine-Threonine Kinases/chemistry/*metabolism
MH  - *Signal Transduction
MH  - Tumor Suppressor Proteins/*metabolism
PMC - PMC3168995
EDAT- 2011/06/17 06:00
MHDA- 2012/03/02 06:00
PMCR- 2011/06/01
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - cddis201153 [pii]
AID - 10.1038/cddis.2011.53 [doi]
PST - epublish
SO  - Cell Death Dis. 2011 Jun 16;2(6):e172. doi: 10.1038/cddis.2011.53.