PMID- 21677748
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20220310
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 474
IP  - 7351
DP  - 2011 Jun 15
TI  - Microenvironmental regulation of stem cells in intestinal homeostasis and cancer.
PG  - 318-26
LID - 10.1038/nature10212 [doi]
AB  - The identification of intestinal stem cells as well as their malignant 
      counterparts, colon cancer stem cells, has undergone rapid development in recent 
      years. Under physiological conditions, intestinal homeostasis is a carefully 
      balanced and efficient interplay between stem cells, their progeny and the 
      microenvironment. These interactions regulate the astonishingly rapid renewal of 
      the intestinal epithelial layer, which consequently puts us at serious risk of 
      developing cancer. Here we highlight the microenvironment-derived signals that 
      regulate stem-cell fate and epithelial differentiation. As our understanding of 
      normal intestinal crypt homeostasis grows, these developments may point towards 
      new insights into the origin of cancer and the maintenance and regulation of 
      cancer stem cells.
FAU - Medema, Jan Paul
AU  - Medema JP
AD  - Laboratory of Experimental Oncology and Radiobiology, Center for Experimental 
      Molecular Medicine, Academic Medical Center, Amsterdam 1105AZ, The Netherlands. 
      j.p.medema@amc.nl
FAU - Vermeulen, Louis
AU  - Vermeulen L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110615
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - Animals
MH  - *Homeostasis
MH  - Humans
MH  - Intestinal Neoplasms/genetics/*pathology
MH  - Intestines/cytology/*pathology/*physiology/physiopathology
MH  - Neoplastic Stem Cells/metabolism/pathology
MH  - Signal Transduction
MH  - Stem Cells/*cytology/pathology/*physiology
MH  - *Tumor Microenvironment/genetics
EDAT- 2011/06/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - nature10212 [pii]
AID - 10.1038/nature10212 [doi]
PST - epublish
SO  - Nature. 2011 Jun 15;474(7351):318-26. doi: 10.1038/nature10212.