PMID- 21701511
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20240210
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Print)
IS  - 1474-175X (Linking)
VI  - 11
IP  - 7
DP  - 2011 Jun 24
TI  - DNA interstrand crosslink repair and cancer.
PG  - 467-80
LID - 10.1038/nrc3088 [doi]
AB  - Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent 
      transcription and replication by inhibiting DNA strand separation. Agents that 
      induce ICLs were one of the earliest, and are still the most widely used, forms 
      of chemotherapeutic drug. Only recently, however, have we begun to understand how 
      cells repair these lesions. Important insights have come from studies of 
      individuals with Fanconi anaemia (FA), a rare genetic disorder that leads to ICL 
      sensitivity. Understanding how the FA pathway links nucleases, helicases and 
      other DNA-processing enzymes should lead to more targeted uses of ICL-inducing 
      agents in cancer treatment and could provide novel insights into drug resistance.
FAU - Deans, Andrew J
AU  - Deans AJ
AD  - London Research Institute, Cancer Research UK, Clare Hall Laboratories, South 
      Mimms EN63LD, UK.
FAU - West, Stephen C
AU  - West SC
LA  - eng
GR  - 11582/CRUK_/Cancer Research UK/United Kingdom
GR  - 249145/ERC_/European Research Council/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110624
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cross-Linking Reagents)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Cross-Linking Reagents/*pharmacology
MH  - DNA Damage
MH  - *DNA Repair
MH  - Drug Resistance, Neoplasm
MH  - Fanconi Anemia/genetics
MH  - Humans
MH  - Neoplasms/*drug therapy/etiology/genetics
MH  - Recombination, Genetic
PMC - PMC3560328
MID - EMS51353
OID - NLM: EMS51353
EDAT- 2011/06/28 06:00
MHDA- 2011/08/25 06:00
PMCR- 2013/01/31
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
PHST- 2013/01/31 00:00 [pmc-release]
AID - nrc3088 [pii]
AID - 10.1038/nrc3088 [doi]
PST - epublish
SO  - Nat Rev Cancer. 2011 Jun 24;11(7):467-80. doi: 10.1038/nrc3088.