PMID- 21708145
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20110725
IS  - 1095-564X (Electronic)
IS  - 0012-1606 (Linking)
VI  - 356
IP  - 2
DP  - 2011 Aug 15
TI  - Multipotent neural stem cells generate glial cells of the central complex through 
      transit amplifying intermediate progenitors in Drosophila brain development.
PG  - 553-65
LID - 10.1016/j.ydbio.2011.06.013 [doi]
AB  - The neural stem cells that give rise to the neural lineages of the brain can 
      generate their progeny directly or through transit amplifying intermediate neural 
      progenitor cells (INPs). The INP-producing neural stem cells in Drosophila are 
      called type II neuroblasts, and their neural progeny innervate the central 
      complex, a prominent integrative brain center. Here we use genetic lineage 
      tracing and clonal analysis to show that the INPs of these type II neuroblast 
      lineages give rise to glial cells as well as neurons during postembryonic brain 
      development. Our data indicate that two main types of INP lineages are generated, 
      namely mixed neuronal/glial lineages and neuronal lineages. Genetic 
      loss-of-function and gain-of-function experiments show that the gcm gene is 
      necessary and sufficient for gliogenesis in these lineages. The INP-derived glial 
      cells, like the INP-derived neuronal cells, make major contributions to the 
      central complex. In postembryonic development, these INP-derived glial cells 
      surround the entire developing central complex neuropile, and once the major 
      compartments of the central complex are formed, they also delimit each of these 
      compartments. During this process, the number of these glial cells in the central 
      complex is increased markedly through local proliferation based on glial cell 
      mitosis. Taken together, these findings uncover a novel and complex form of 
      neurogliogenesis in Drosophila involving transit amplifying intermediate 
      progenitors. Moreover, they indicate that type II neuroblasts are remarkably 
      multipotent neural stem cells that can generate both the neuronal and the glial 
      progeny that make major contributions to one and the same complex brain 
      structure.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Viktorin, Gudrun
AU  - Viktorin G
AD  - Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland. 
      gudrunviktorin@gmail.com
FAU - Riebli, Nadia
AU  - Riebli N
FAU - Popkova, Anna
AU  - Popkova A
FAU - Giangrande, Angela
AU  - Giangrande A
FAU - Reichert, Heinrich
AU  - Reichert H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110625
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
SB  - IM
MH  - Animals
MH  - Brain/*embryology
MH  - Cell Lineage
MH  - Cell Proliferation
MH  - Drosophila melanogaster/*embryology
MH  - Multipotent Stem Cells/*cytology
MH  - Neural Stem Cells/*cytology
MH  - *Neurogenesis
MH  - Neuroglia/*cytology
EDAT- 2011/06/29 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/29 06:00
PHST- 2010/12/16 00:00 [received]
PHST- 2011/05/27 00:00 [revised]
PHST- 2011/06/11 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0012-1606(11)01035-9 [pii]
AID - 10.1016/j.ydbio.2011.06.013 [doi]
PST - ppublish
SO  - Dev Biol. 2011 Aug 15;356(2):553-65. doi: 10.1016/j.ydbio.2011.06.013. Epub 2011 
      Jun 25.