PMID- 21778362
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20230207
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 333
IP  - 6048
DP  - 2011 Sep 9
TI  - Synaptic pruning by microglia is necessary for normal brain development.
PG  - 1456-8
LID - 10.1126/science.1202529 [doi]
AB  - Microglia are highly motile phagocytic cells that infiltrate and take up 
      residence in the developing brain, where they are thought to provide a 
      surveillance and scavenging function. However, although microglia have been shown 
      to engulf and clear damaged cellular debris after brain insult, it remains less 
      clear what role microglia play in the uninjured brain. Here, we show that 
      microglia actively engulf synaptic material and play a major role in synaptic 
      pruning during postnatal development in mice. These findings link microglia 
      surveillance to synaptic maturation and suggest that deficits in microglia 
      function may contribute to synaptic abnormalities seen in some neurodevelopmental 
      disorders.
FAU - Paolicelli, Rosa C
AU  - Paolicelli RC
AD  - Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Via Ramarini 
      32, 00015 Monterotondo, Italy.
FAU - Bolasco, Giulia
AU  - Bolasco G
FAU - Pagani, Francesca
AU  - Pagani F
FAU - Maggi, Laura
AU  - Maggi L
FAU - Scianni, Maria
AU  - Scianni M
FAU - Panzanelli, Patrizia
AU  - Panzanelli P
FAU - Giustetto, Maurizio
AU  - Giustetto M
FAU - Ferreira, Tiago Alves
AU  - Ferreira TA
FAU - Guiducci, Eva
AU  - Guiducci E
FAU - Dumas, Laura
AU  - Dumas L
FAU - Ragozzino, Davide
AU  - Ragozzino D
FAU - Gross, Cornelius T
AU  - Gross CT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110721
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (CX3C Chemokine Receptor 1)
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (Cx3cl1 protein, mouse)
RN  - 0 (Cx3cr1 protein, mouse)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, HIV)
RN  - 0 (Snap25 protein, mouse)
RN  - 0 (Synaptosomal-Associated Protein 25)
RN  - EC 2.7.4.8 (Guanylate Kinases)
SB  - IM
CIN - Nat Rev Neurosci. 2011 Aug 19;12(9):492-3. doi: 10.1038/nrn3095. PMID: 21852797
CIN - Science. 2011 Sep 9;333(6048):1391-2. doi: 10.1126/science.1212112. PMID: 
      21903801
MH  - Animals
MH  - Brain/*growth & development/physiology
MH  - CX3C Chemokine Receptor 1
MH  - Chemokine CX3CL1/metabolism
MH  - Dendritic Spines/physiology/ultrastructure
MH  - Disks Large Homolog 4 Protein
MH  - Excitatory Postsynaptic Potentials
MH  - Guanylate Kinases/analysis
MH  - Hippocampus/*growth & development/*physiology
MH  - Long-Term Synaptic Depression
MH  - Membrane Proteins/analysis
MH  - Mice
MH  - Mice, Knockout
MH  - Microglia/*physiology
MH  - Miniature Postsynaptic Potentials
MH  - Neuronal Plasticity
MH  - Patch-Clamp Techniques
MH  - Pyramidal Cells/physiology
MH  - Receptors, Chemokine/genetics/metabolism
MH  - Receptors, Cytokine/genetics/metabolism
MH  - Receptors, HIV/genetics/metabolism
MH  - Signal Transduction
MH  - Synapses/*physiology
MH  - Synaptosomal-Associated Protein 25/analysis
EDAT- 2011/07/23 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - science.1202529 [pii]
AID - 10.1126/science.1202529 [doi]
PST - ppublish
SO  - Science. 2011 Sep 9;333(6048):1456-8. doi: 10.1126/science.1202529. Epub 2011 Jul 
      21.