PMID- 2178330
OWN - NLM
STAT- MEDLINE
DCOM- 19910318
LR  - 20220409
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 28
IP  - 6
DP  - 1990 Dec
TI  - Effects of treatment on long-term survivors with malignant astrocytomas.
PG  - 818-22
AB  - We reviewed the records of 160 consecutive patients with glioblastoma and 
      anaplastic astrocytoma to evaluate the long-term consequences of radiation 
      therapy and chemotherapy. We defined long-term survivors as those patients with 
      glioblastoma or anaplastic astrocytoma who lived at least 100% longer than median 
      survival of historical controls, for example, 2 years for patients with 
      glioblastoma and 4 years for patients with anaplastic astrocytoma. There were 9 
      (5.6%) long-term survivors. Three (30%) became demented and died without evidence 
      of tumor recurrence. One, after survival of 10 years, died of tumor recurrence. 
      Of the remaining survivors, 2 (22%) have significantly impaired short-term memory 
      function and other neurological deficits such as gait apraxia. Three (30%) can 
      function independently. It is likely but cannot be proved that it is radiotherapy 
      and not chemotherapy that is the causal factor of this dismal therapeutic 
      outcome. Our study suggests restraint in the use of radiotherapy for patients 
      with brain tumors that have more favorable prognoses than glioblastomas and 
      anaplastic astrocytomas, such as low-grade astrocytomas and oligodendrogliomas.
FAU - Imperato, J P
AU  - Imperato JP
AD  - Department of Radiology, Northwestern Medical School, Evanston Hospital, IL 
      60201.
FAU - Paleologos, N A
AU  - Paleologos NA
FAU - Vick, N A
AU  - Vick NA
LA  - eng
GR  - P50 NS200323/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Antineoplastic Agents)
SB  - IM
CIN - Ann Neurol. 1991 Jul;30(1):115-6. PMID: 1929224
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/therapeutic use
MH  - Astrocytoma/diagnostic imaging/*drug therapy/mortality/radiotherapy
MH  - Brain/diagnostic imaging/pathology
MH  - Brain Neoplasms/diagnostic imaging/*drug therapy/mortality/radiotherapy
MH  - Combined Modality Therapy
MH  - Female
MH  - Glioblastoma/diagnostic imaging/*drug therapy/mortality/radiotherapy
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Time Factors
MH  - Tomography, X-Ray Computed
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - 10.1002/ana.410280614 [doi]
PST - ppublish
SO  - Ann Neurol. 1990 Dec;28(6):818-22. doi: 10.1002/ana.410280614.