PMID- 21808241
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20221109
IS  - 1476-4679 (Electronic)
IS  - 1465-7392 (Print)
IS  - 1465-7392 (Linking)
VI  - 13
IP  - 8
DP  - 2011 Aug 1
TI  - The Hippo pathway in organ size control, tissue regeneration and stem cell 
      self-renewal.
PG  - 877-83
LID - 10.1038/ncb2303 [doi]
AB  - Precise control of organ size is crucial during animal development and 
      regeneration. In Drosophila and mammals, studies over the past decade have 
      uncovered a critical role for the Hippo tumour-suppressor pathway in the 
      regulation of organ size. Dysregulation of this pathway leads to massive 
      overgrowth of tissue. The Hippo signalling pathway is highly conserved and limits 
      organ size by phosphorylating and inhibiting the transcription co-activators YAP 
      and TAZ in mammals and Yki in Drosophila, key regulators of proliferation and 
      apoptosis. The Hippo pathway also has a critical role in the self-renewal and 
      expansion of stem cells and tissue-specific progenitor cells, and has important 
      functions in tissue regeneration. Emerging evidence shows that the Hippo pathway 
      is regulated by cell polarity, cell adhesion and cell junction proteins. In this 
      review we summarize current understanding of the composition and regulation of 
      the Hippo pathway, and discuss how cell polarity and cell adhesion proteins 
      inform the role of this pathway in organ size control and regeneration.
FAU - Zhao, Bin
AU  - Zhao B
AD  - Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
FAU - Tumaneng, Karen
AU  - Tumaneng K
FAU - Guan, Kun-Liang
AU  - Guan KL
LA  - eng
GR  - R01 CA132809/CA/NCI NIH HHS/United States
GR  - R01 GM051586/GM/NIGMS NIH HHS/United States
GR  - T32 GM007752/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110801
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Cell Adhesion/physiology
MH  - Cell Polarity/physiology
MH  - Drosophila/cytology/physiology
MH  - Drosophila Proteins/*physiology
MH  - Humans
MH  - Intercellular Junctions/physiology
MH  - Intracellular Signaling Peptides and Proteins/*physiology
MH  - Mice
MH  - Models, Biological
MH  - Organ Size/*physiology
MH  - Protein Serine-Threonine Kinases/*physiology
MH  - Regeneration/*physiology
MH  - Signal Transduction
MH  - Stem Cells/*cytology/*physiology
PMC - PMC3987945
MID - NIHMS563889
EDAT- 2011/08/03 06:00
MHDA- 2011/10/01 06:00
PMCR- 2014/04/15
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PHST- 2014/04/15 00:00 [pmc-release]
AID - ncb2303 [pii]
AID - 10.1038/ncb2303 [doi]
PST - epublish
SO  - Nat Cell Biol. 2011 Aug 1;13(8):877-83. doi: 10.1038/ncb2303.