PMID- 21879451
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20110831
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 206
DP  - 2011
TI  - Characterization of nuclear sirtuins: molecular mechanisms and physiological 
      relevance.
PG  - 189-224
LID - 10.1007/978-3-642-21631-2_9 [doi]
AB  - Sirtuins are protein deacetylases/mono-ADP-ribosyltransferases found in organisms 
      ranging from bacteria to humans. This group of enzymes relies on nicotinamide 
      adenine dinucleotide (NAD(+)) as a cofactor linking their activity to the 
      cellular metabolic status. Originally found in yeast, Sir2 was discovered as a 
      silencing factor and has been shown to mediate the effects of calorie restriction 
      on lifespan extension. In mammals seven homologs (SIRT1-7) exist which evolved to 
      have specific biological outcomes depending on the particular cellular context, 
      their interacting proteins, and the genomic loci to where they are actively 
      targeted. Sirtuins biological roles are highlighted in the early lethal 
      phenotypes observed in the deficient murine models. In this chapter, we summarize 
      current concepts on non-metabolic functions for sirtuins, depicting this broad 
      family from yeast to mammals.
FAU - Toiber, Debra
AU  - Toiber D
AD  - The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, 
      MA, USA.
FAU - Sebastian, Carlos
AU  - Sebastian C
FAU - Mostoslavsky, Raul
AU  - Mostoslavsky R
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Fungal Proteins)
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans Proteins/*metabolism
MH  - Cell Nucleus/*enzymology
MH  - Drosophila Proteins/*metabolism
MH  - Fungal Proteins/*metabolism
MH  - Humans
MH  - Sirtuins/*metabolism
EDAT- 2011/09/01 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/978-3-642-21631-2_9 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2011;206:189-224. doi: 10.1007/978-3-642-21631-2_9.