PMID- 21982230
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20220410
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 9
IP  - 4
DP  - 2011 Oct 4
TI  - Metabolic regulation of hematopoietic stem cells in the hypoxic niche.
PG  - 298-310
LID - 10.1016/j.stem.2011.09.010 [doi]
AB  - Tissue homeostasis over the life of an organism relies on both self-renewal and 
      multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside 
      in a hypoxic bone marrow environment, and their metabolic status is distinct from 
      that of their differentiated progeny. HSCs generate energy mainly via anaerobic 
      metabolism by maintaining a high rate of glycolysis. This metabolic balance 
      promotes HSC maintenance by limiting the production of reactive oxygen species, 
      but leaves HSCs susceptible to changes in redox status. In this review, we 
      discuss the importance of oxygen homeostasis and energy metabolism for 
      maintenance of HSC function and long-term self-renewal.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Suda, Toshio
AU  - Suda T
AD  - Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental 
      Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. 
      sudato@sc.itc.keio.ac.jp
FAU - Takubo, Keiyo
AU  - Takubo K
FAU - Semenza, Gregg L
AU  - Semenza GL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
SB  - IM
MH  - Cell Cycle
MH  - Cell Hypoxia
MH  - Cellular Microenvironment
MH  - Hematopoietic Stem Cells/cytology/*metabolism
MH  - Humans
MH  - Signal Transduction
MH  - *Stem Cell Niche
EDAT- 2011/10/11 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - S1934-5909(11)00441-3 [pii]
AID - 10.1016/j.stem.2011.09.010 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2011 Oct 4;9(4):298-310. doi: 10.1016/j.stem.2011.09.010.