PMID- 21982232
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20220318
IS  - 1875-9777 (Electronic)
IS  - 1934-5909 (Print)
IS  - 1875-9777 (Linking)
VI  - 9
IP  - 4
DP  - 2011 Oct 4
TI  - Sox2(+) adult stem and progenitor cells are important for tissue regeneration and 
      survival of mice.
PG  - 317-29
LID - 10.1016/j.stem.2011.09.001 [doi]
AB  - The transcription factor Sox2 maintains the pluripotency of early embryonic cells 
      and regulates the formation of several epithelia during fetal development. 
      Whether Sox2 continues to play a role in adult tissues remains largely unknown. 
      We show here that Sox2 marks adult cells in several epithelial tissues where its 
      expression has not previously been characterized, including the stomach, cervix, 
      anus, testes, lens, and multiple glands. Genetic lineage tracing and 
      transplantation experiments demonstrate that Sox2-expressing cells continuously 
      give rise to mature cell types within these tissues, documenting their 
      self-renewal and differentiation potentials. Consistent with these findings, 
      ablation of Sox2(+) cells in mice results in a disruption of epithelial tissue 
      homeostasis and lethality. Developmental fate mapping reveals that Sox2(+) adult 
      stem cells originate from fetal Sox2(+) tissue progenitors. Thus, our results 
      identify Sox2 expression in numerous adult endodermal and ectodermal stem cell 
      compartments, which are critical for normal tissue regeneration and survival.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Arnold, Katrin
AU  - Arnold K
AD  - Howard Hughes Medical Institute and Department of Stem Cell and Regenerative 
      Biology, Harvard University and Harvard Medical School, Cambridge, MA 02138, USA.
FAU - Sarkar, Abby
AU  - Sarkar A
FAU - Yram, Mary Anna
AU  - Yram MA
FAU - Polo, Jose M
AU  - Polo JM
FAU - Bronson, Rod
AU  - Bronson R
FAU - Sengupta, Sumitra
AU  - Sengupta S
FAU - Seandel, Marco
AU  - Seandel M
FAU - Geijsen, Niels
AU  - Geijsen N
FAU - Hochedlinger, Konrad
AU  - Hochedlinger K
LA  - eng
GR  - DP2 OD003266/OD/NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R01HD058013-01A1/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (Sox2 protein, mouse)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - P9G3CKZ4P5 (Ganciclovir)
SB  - IM
CIN - Cell Stem Cell. 2011 Oct 4;9(4):283-4. PMID: 21982223
MH  - Adult Stem Cells/*cytology/drug effects/*metabolism
MH  - Animals
MH  - Cell Compartmentation
MH  - Cell Lineage/drug effects/genetics
MH  - Cell Proliferation/drug effects
MH  - Epithelium/drug effects/metabolism
MH  - Ganciclovir/pharmacology
MH  - Green Fluorescent Proteins/metabolism
MH  - Homeostasis/drug effects
MH  - Infertility, Male/pathology
MH  - Male
MH  - Mice
MH  - Multipotent Stem Cells/cytology/drug effects/metabolism
MH  - Recombinant Fusion Proteins/metabolism
MH  - *Regeneration/drug effects
MH  - SOXB1 Transcription Factors/*metabolism
MH  - Spermatogenesis/drug effects
MH  - Spermatozoa/metabolism/pathology
MH  - Stomach/cytology
MH  - Survival Analysis
MH  - Testis/drug effects/pathology
PMC - PMC3538360
MID - NIHMS328957
EDAT- 2011/10/11 06:00
MHDA- 2012/04/17 06:00
PMCR- 2013/01/07
CRDT- 2011/10/11 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/08/05 00:00 [revised]
PHST- 2011/09/09 00:00 [accepted]
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
PHST- 2013/01/07 00:00 [pmc-release]
AID - S1934-5909(11)00432-2 [pii]
AID - 10.1016/j.stem.2011.09.001 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2011 Oct 4;9(4):317-29. doi: 10.1016/j.stem.2011.09.001.