PMID- 22177113
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20211021
IS  - 1879-0364 (Electronic)
IS  - 1369-5274 (Print)
IS  - 1369-5274 (Linking)
VI  - 15
IP  - 1
DP  - 2012 Feb
TI  - Role of mucus layers in gut infection and inflammation.
PG  - 57-62
LID - 10.1016/j.mib.2011.11.002 [doi]
AB  - The intestinal mucus is an efficient system for protecting the epithelium from 
      bacteria by promoting their clearance and separating them from the epithelial 
      cells, thereby inhibiting inflammation and infection. The function of the colon 
      inner mucus layer is especially important as this explains how we can harbor the 
      large number of bacteria in our gut. The major component of this mucus system is 
      the MUC2 mucin which organizes the mucus by its enormously large net-like 
      polymers. Pathogenic microorganisms, in turn, have developed mechanisms for 
      circumventing this well-organized mucus protective system.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Hansson, Gunnar C
AU  - Hansson GC
AD  - Dept. Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden. 
      gunnar.hansson@medkem.gu.se
LA  - eng
GR  - U01 AI095473/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111214
PL  - England
TA  - Curr Opin Microbiol
JT  - Current opinion in microbiology
JID - 9815056
SB  - IM
MH  - Animals
MH  - Bacteria/immunology/pathogenicity
MH  - Bacterial Infections/immunology/microbiology
MH  - Enteritis/*immunology/*microbiology
MH  - Gastrointestinal Tract/*immunology/*microbiology
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Intestinal Mucosa/immunology/microbiology
MH  - Mucus/*immunology/*microbiology
PMC - PMC3716454
MID - NIHMS478688
EDAT- 2011/12/20 06:00
MHDA- 2012/05/12 06:00
PMCR- 2013/07/19
CRDT- 2011/12/20 06:00
PHST- 2011/08/31 00:00 [received]
PHST- 2011/10/27 00:00 [revised]
PHST- 2011/11/08 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
PHST- 2013/07/19 00:00 [pmc-release]
AID - S1369-5274(11)00185-8 [pii]
AID - 10.1016/j.mib.2011.11.002 [doi]
PST - ppublish
SO  - Curr Opin Microbiol. 2012 Feb;15(1):57-62. doi: 10.1016/j.mib.2011.11.002. Epub 
      2011 Dec 14.