PMID- 22258607
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20220410
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 481
IP  - 7381
DP  - 2012 Jan 18
TI  - The DNA damage response and cancer therapy.
PG  - 287-94
LID - 10.1038/nature10760 [doi]
AB  - Genomic instability is one of the most pervasive characteristics of tumour cells 
      and is probably the combined effect of DNA damage, tumour-specific DNA repair 
      defects, and a failure to stop or stall the cell cycle before the damaged DNA is 
      passed on to daughter cells. Although these processes drive genomic instability 
      and ultimately the disease process, they also provide therapeutic opportunities. 
      A better understanding of the cellular response to DNA damage will not only 
      inform our knowledge of cancer development but also help to refine the 
      classification as well as the treatment of the disease.
FAU - Lord, Christopher J
AU  - Lord CJ
AD  - The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 
      Fulham Road, London SW3 6JB, UK. chris.lord@icr.ac.uk
FAU - Ashworth, Alan
AU  - Ashworth A
LA  - eng
GR  - BREAST CANCER NOW RESEARCH CENTRE/BCN_/Breast Cancer Now/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120118
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Poly(ADP-ribose) Polymerase Inhibitors)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
SB  - IM
MH  - *DNA Damage/drug effects
MH  - DNA Repair/drug effects
MH  - Genomic Instability/drug effects
MH  - Humans
MH  - Molecular Targeted Therapy
MH  - Neoplasms/*genetics/pathology/*therapy
MH  - Neoplastic Stem Cells/drug effects/pathology
MH  - Poly(ADP-ribose) Polymerase Inhibitors
MH  - Poly(ADP-ribose) Polymerases/metabolism
MH  - Tumor Microenvironment/drug effects
EDAT- 2012/01/20 06:00
MHDA- 2012/03/07 06:00
CRDT- 2012/01/20 06:00
PHST- 2012/01/20 06:00 [entrez]
PHST- 2012/01/20 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - nature10760 [pii]
AID - 10.1038/nature10760 [doi]
PST - epublish
SO  - Nature. 2012 Jan 18;481(7381):287-94. doi: 10.1038/nature10760.