PMID- 22337149
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20250424
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 12
IP  - 3
DP  - 2012 Feb 16
TI  - The insulin and insulin-like growth factor receptor family in neoplasia: an 
      update.
PG  - 159-69
LID - 10.1038/nrc3215 [doi]
AB  - Although several early phase clinical trials raised enthusiasm for the use of 
      insulin-like growth factor I receptor (IGF1R)-specific antibodies for cancer 
      treatment, initial Phase III results in unselected patients have been 
      disappointing. Further clinical studies may benefit from the use of predictive 
      biomarkers to identify probable responders, the use of rational combination 
      therapies and the consideration of alternative targeting strategies, such as 
      ligand-specific antibodies and receptor-specific tyrosine kinase inhibitors. 
      Targeting insulin and IGF signalling also needs to be considered in the broader 
      context of the pathophysiology that relates obesity and diabetes to neoplasia, 
      and the effects of anti-diabetic drugs, including metformin, on cancer risk and 
      prognosis. The insulin and IGFI receptor family is also relevant to the 
      development of PI3K-AKT pathway inhibitors.
FAU - Pollak, Michael
AU  - Pollak M
AD  - Lady Davis Research Institute and McGill University, Montreal, Quebec H3T1E2, 
      Canada. michael.pollak@mcgill.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120216
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Insulin)
RN  - 0 (Receptors, Somatomedin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Multigene Family
MH  - Neoplasms/drug therapy/genetics/*metabolism
MH  - Receptors, Somatomedin/genetics/*metabolism
MH  - Signal Transduction
EDAT- 2012/02/18 06:00
MHDA- 2012/04/20 06:00
CRDT- 2012/02/17 06:00
PHST- 2012/02/17 06:00 [entrez]
PHST- 2012/02/18 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - nrc3215 [pii]
AID - 10.1038/nrc3215 [doi]
PST - epublish
SO  - Nat Rev Cancer. 2012 Feb 16;12(3):159-69. doi: 10.1038/nrc3215.