PMID- 22386732
OWN - NLM
STAT- MEDLINE
DCOM- 20120629
LR  - 20240109
IS  - 1471-499X (Electronic)
IS  - 1471-4914 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Mar
TI  - The pharmacology of curcumin: is it the degradation products?
PG  - 138-44
LID - 10.1016/j.molmed.2012.01.004 [doi]
AB  - The natural product curcumin has gained considerable attention in recent years 
      for its multiple pharmacological activities, but more efforts are needed to 
      understand how curcumin can have these pharmacological effects considering its 
      low bioavailability. In addition, it is unclear how curcumin exerts inhibitory 
      effects against numerous enzymes, especially those that cannot accommodate 
      curcumin within recognized binding pockets. By analyzing the similarities between 
      the biological activities of curcumin and its degradation products against 
      diseases such as Alzheimer's disease and cancer, as well as the preferential 
      inhibition of some enzymes by degradation products, it appears that the bioactive 
      degradation products may contribute to the pharmacological effects of curcumin. 
      This possibility should be given full attention when elucidating the pharmacology 
      of this promising natural product for various diseases.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Shen, Liang
AU  - Shen L
AD  - Shandong Provincial Research Center for Bioinformatic Engineering and Technique, 
      Shandong University of Technology, Zibo 255049, PR China. shen@sdut.edu.cn
FAU - Ji, Hong-Fang
AU  - Ji HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120301
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - IT942ZTH98 (Curcumin)
SB  - IM
CIN - Trends Mol Med. 2012 Jul;18(7):361-3; author reply 363-4. PMID: 22652257
MH  - Alzheimer Disease/*drug therapy/metabolism
MH  - Animals
MH  - Curcumin/chemistry/*metabolism/*pharmacology
MH  - Humans
MH  - Neoplasms/*drug therapy/metabolism
MH  - Proteolysis
EDAT- 2012/03/06 06:00
MHDA- 2012/06/30 06:00
CRDT- 2012/03/06 06:00
PHST- 2011/10/20 00:00 [received]
PHST- 2012/01/10 00:00 [revised]
PHST- 2012/01/13 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2012/06/30 06:00 [medline]
AID - S1471-4914(12)00007-X [pii]
AID - 10.1016/j.molmed.2012.01.004 [doi]
PST - ppublish
SO  - Trends Mol Med. 2012 Mar;18(3):138-44. doi: 10.1016/j.molmed.2012.01.004. Epub 
      2012 Mar 1.