PMID- 22404630
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20220318
IS  - 1545-4509 (Electronic)
IS  - 0066-4154 (Print)
IS  - 0066-4154 (Linking)
VI  - 81
DP  - 2012
TI  - Ubiquitin and proteasomes in transcription.
PG  - 177-201
LID - 10.1146/annurev-biochem-052110-120012 [doi]
AB  - Regulation of gene transcription is vitally important for the maintenance of 
      normal cellular homeostasis. Failure to correctly regulate gene expression, or to 
      deal with problems that arise during the transcription process, can lead to 
      cellular catastrophe and disease. One of the ways cells cope with the challenges 
      of transcription is by making extensive use of the proteolytic and nonproteolytic 
      activities of the ubiquitin-proteasome system (UPS). Here, we review recent 
      evidence showing deep mechanistic connections between the transcription and 
      ubiquitin-proteasome systems. Our goal is to leave the reader with a sense that 
      just about every step in transcription-from transcription initiation through to 
      export of mRNA from the nucleus-is influenced by the UPS and that all major arms 
      of the system--from the first step in ubiquitin (Ub) conjugation through to the 
      proteasome-are recruited into transcriptional processes to provide regulation, 
      directionality, and deconstructive power.
FAU - Geng, Fuqiang
AU  - Geng F
AD  - Department of Cell and Developmental Biology, Vanderbilt University School of 
      Medicine, Nashville, Tennessee 37232-8240, USA. fuqiang.geng@vanderbilt.edu
FAU - Wenzel, Sabine
AU  - Wenzel S
FAU - Tansey, William P
AU  - Tansey WP
LA  - eng
GR  - R01 GM067728/GM/NIGMS NIH HHS/United States
GR  - GM067728/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120308
PL  - United States
TA  - Annu Rev Biochem
JT  - Annual review of biochemistry
JID - 2985150R
RN  - 0 (Transcription Factors)
RN  - EC 2.7.7.6 (DNA-Directed RNA Polymerases)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Animals
MH  - DNA-Directed RNA Polymerases/metabolism
MH  - Humans
MH  - Proteasome Endopeptidase Complex/*metabolism
MH  - *Proteolysis
MH  - Transcription Factors/chemistry/*metabolism
MH  - *Transcription, Genetic
MH  - *Ubiquitination
PMC - PMC3637986
MID - NIHMS443423
EDAT- 2012/03/13 06:00
MHDA- 2012/08/22 06:00
PMCR- 2013/04/28
CRDT- 2012/03/13 06:00
PHST- 2012/03/13 06:00 [entrez]
PHST- 2012/03/13 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
PHST- 2013/04/28 00:00 [pmc-release]
AID - 10.1146/annurev-biochem-052110-120012 [doi]
PST - ppublish
SO  - Annu Rev Biochem. 2012;81:177-201. doi: 10.1146/annurev-biochem-052110-120012. 
      Epub 2012 Mar 8.