PMID- 22573310
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20220408
IS  - 1523-5866 (Electronic)
IS  - 1522-8517 (Print)
IS  - 1522-8517 (Linking)
VI  - 14
IP  - 8
DP  - 2012 Aug
TI  - The molecular profile of microglia under the influence of glioma.
PG  - 958-78
LID - 10.1093/neuonc/nos116 [doi]
AB  - Microglia, which contribute substantially to the tumor mass of glioblastoma, have 
      been shown to play an important role in glioma growth and invasion. While a large 
      number of experimental studies on functional attributes of microglia in glioma 
      provide evidence for their tumor-supporting roles, there also exist hints in 
      support of their anti-tumor properties. Microglial activities during glioma 
      progression seem multifaceted. They have been attributed to the receptors 
      expressed on the microglia surface, to glioma-derived molecules that have an 
      effect on microglia, and to the molecules released by microglia in response to 
      their environment under glioma control, which can have autocrine effects. In this 
      paper, the microglia and glioma literature is reviewed. We provide a synopsis of 
      the molecular profile of microglia under the influence of glioma in order to help 
      establish a rational basis for their potential therapeutic use. The ability of 
      microglia precursors to cross the blood-brain barrier makes them an attractive 
      target for the development of novel cell-based treatments of malignant glioma.
FAU - Li, Wei
AU  - Li W
AD  - Brain Tumor Research Laboratories, The Brain and Mind Research Institute, 
      University of Sydney, 94 Mallett St, Camperdown, Sydney, NSW 2050, Australia.
FAU - Graeber, Manuel B
AU  - Graeber MB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120509
PL  - England
TA  - Neuro Oncol
JT  - Neuro-oncology
JID - 100887420
SB  - IM
CIN - Neuro Oncol. 2012 Aug;14(8):957. PMID: 22851682
MH  - Animals
MH  - Brain Neoplasms/immunology/*pathology/therapy
MH  - Glioma/immunology/*pathology/therapy
MH  - Humans
MH  - Microglia/*pathology
PMC - PMC3408253
EDAT- 2012/05/11 06:00
MHDA- 2012/12/12 06:00
PMCR- 2013/08/01
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - nos116 [pii]
AID - 10.1093/neuonc/nos116 [doi]
PST - ppublish
SO  - Neuro Oncol. 2012 Aug;14(8):958-78. doi: 10.1093/neuonc/nos116. Epub 2012 May 9.