PMID- 22595146
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20220408
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 164
IP  - 2
DP  - 2012 Dec 10
TI  - Macromolecular therapeutics in cancer treatment: the EPR effect and beyond.
PG  - 138-44
LID - S0168-3659(12)00319-7 [pii]
LID - 10.1016/j.jconrel.2012.04.038 [doi]
AB  - In this review, I have discussed various issues of the cancer drug targeting 
      primarily related to the EPR (enhanced permeability and retention) effect, which 
      utilized nanomedicine or macromolecular drugs. The content goes back to the 
      development of the first polymer-protein conjugate anticancer agent SMANCS and 
      development of the arterial infusion in Lipiodol formulation into the tumor 
      feeding artery (hepatic artery for hepatoma). The brief account on the EPR effect 
      and its definition, factors involved, heterogeneity, and various methods of 
      augmentation of the EPR effect, which showed remarkably improved clinical 
      outcomes are also discussed. Various obstacles involved in drug developments and 
      commercialization are also discussed through my personal experience and 
      recollections.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Maeda, Hiroshi
AU  - Maeda H
AD  - Institute of DDS Research, Sojo University, 4-22-1, Ikeda, Kumamoto, 860-0082, 
      Japan. hirmaeda@ph.sojo-u.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120501
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Polymers)
RN  - 8008-53-5 (Ethiodized Oil)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage
MH  - *Drug Delivery Systems
MH  - Drug and Narcotic Control
MH  - Ethiodized Oil/administration & dosage
MH  - Humans
MH  - Marketing
MH  - Neoplasms/drug therapy/*metabolism
MH  - Permeability
MH  - Polymers/administration & dosage
EDAT- 2012/05/19 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/02/27 00:00 [received]
PHST- 2012/03/22 00:00 [revised]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - S0168-3659(12)00319-7 [pii]
AID - 10.1016/j.jconrel.2012.04.038 [doi]
PST - ppublish
SO  - J Control Release. 2012 Dec 10;164(2):138-44. doi: 10.1016/j.jconrel.2012.04.038. 
      Epub 2012 May 1.