PMID- 22617325
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20240404
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Linking)
VI  - 72
IP  - 15
DP  - 2012 Aug 1
TI  - MET signaling regulates glioblastoma stem cells.
PG  - 3828-38
AB  - Glioblastomas multiforme (GBM) contain highly tumorigenic, self-renewing 
      populations of stem/initiating cells [glioblastoma stem cells (GSC)] that 
      contribute to tumor propagation and treatment resistance. However, our knowledge 
      of the specific signaling pathways that regulate GSCs is limited. The MET 
      tyrosine kinase is known to stimulate the survival, proliferation, and invasion 
      of various cancers including GBM. Here, we identified a distinct fraction of 
      cells expressing a high level of MET in human primary GBM specimens that were 
      preferentially localized in perivascular regions of human GBM biopsy tissues and 
      were found to be highly clonogenic, tumorigenic, and resistant to radiation. 
      Inhibition of MET signaling in GSCs disrupted tumor growth and invasiveness both 
      in vitro and in vivo, suggesting that MET activation is required for GSCs. 
      Together, our findings indicate that MET activation in GBM is a functional 
      requisite for the cancer stem cell phenotype and a promising therapeutic target.
CI  - (c)2012 AACR.
FAU - Joo, Kyeung Min
AU  - Joo KM
AD  - Cancer Stem Cell Research Center, Department of Neurosurgery, Samsung Medical 
      Center and Samsung Biomedical Research Institute, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Jin, Juyoun
AU  - Jin J
FAU - Kim, Eunhee
AU  - Kim E
FAU - Ho Kim, Kang
AU  - Ho Kim K
FAU - Kim, Yonghyun
AU  - Kim Y
FAU - Gu Kang, Bong
AU  - Gu Kang B
FAU - Kang, Youn-Jung
AU  - Kang YJ
FAU - Lathia, Justin D
AU  - Lathia JD
FAU - Cheong, Kwang Ho
AU  - Cheong KH
FAU - Song, Paul H
AU  - Song PH
FAU - Kim, Hyunggee
AU  - Kim H
FAU - Seol, Ho Jun
AU  - Seol HJ
FAU - Kong, Doo-Sik
AU  - Kong DS
FAU - Lee, Jung-Il
AU  - Lee JI
FAU - Rich, Jeremy N
AU  - Rich JN
FAU - Lee, Jeongwu
AU  - Lee J
FAU - Nam, Do-Hyun
AU  - Nam DH
LA  - eng
GR  - K02 NS047409/NS/NINDS NIH HHS/United States
GR  - R01 CA116659/CA/NCI NIH HHS/United States
GR  - R01 CA129958/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Il2rg protein, mouse)
RN  - 0 (Interleukin Receptor Common gamma Subunit)
RN  - 0 (RNA, Small Interfering)
RN  - EC 2.7.10.1 (MET protein, human)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/genetics/*pathology
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Glioblastoma/genetics/*pathology
MH  - Humans
MH  - Interleukin Receptor Common gamma Subunit/genetics
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, Knockout
MH  - Mice, SCID
MH  - Neoplastic Stem Cells/drug effects/metabolism/*pathology/physiology
MH  - Proto-Oncogene Proteins c-met/antagonists & 
      inhibitors/genetics/metabolism/*physiology
MH  - RNA, Small Interfering/pharmacology
MH  - Signal Transduction/drug effects/genetics/physiology
MH  - Tumor Burden/drug effects/genetics
MH  - Tumor Cells, Cultured
EDAT- 2012/05/24 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 0008-5472.CAN-11-3760 [pii]
AID - 10.1158/0008-5472.CAN-11-3760 [doi]
PST - ppublish
SO  - Cancer Res. 2012 Aug 1;72(15):3828-38. doi: 10.1158/0008-5472.CAN-11-3760. Epub 
      2012 May 22.