PMID- 22644962
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20151119
IS  - 1939-005X (Electronic)
IS  - 1939-005X (Linking)
VI  - 4
IP  - 5
DP  - 2012 Sep-Oct
TI  - Gut stem cells in tissue renewal and disease: methods, markers, and myths.
PG  - 475-96
LID - 10.1002/wsbm.1176 [doi]
AB  - Homeostasis in adult tissue is maintained by the activity of a minor population 
      of long-lived resident stem cells. These adult stem cells are defined by two 
      essential attributes, self-renewal and multipotency, and their physiological 
      activity is regulated by a specialized microenvironment, the stem cell niche. 
      These adult stem cells are generally considered to divide infrequently, and cell 
      expansion is mainly achieved through the rapid proliferation of transit 
      amplifying progenitors before they undergo terminal differentiation. Organs that 
      operate in abrasive environments, such as the mucosa of the skin, intestine, and 
      stomach, display a higher tissue turnover rate, which consequently places them at 
      higher risk of developing cancer. Indeed, colorectal cancer (CRC) is one of the 
      most frequent cancers worldwide, with over a million new cases every year. Our 
      understanding of stem cell function in tissue homeostasis and their potential 
      role in cancer development has been greatly hampered by the lack of reliable 
      specific biomarkers, but recent discoveries of membrane bound biomarkers promise 
      great progress in the field. Here we review the current advances toward 
      identifying the stem cells of the gastrointestinal tract and in understanding 
      their microenvironmental regulation, and also discuss their implications for 
      human cancer.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Rizk, Pamela
AU  - Rizk P
AD  - Institute of Medical Biology, A-STAR, Singapore.
FAU - Barker, Nick
AU  - Barker N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120529
PL  - United States
TA  - Wiley Interdiscip Rev Syst Biol Med
JT  - Wiley interdisciplinary reviews. Systems biology and medicine
JID - 101516550
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Biomarkers/metabolism
MH  - Humans
MH  - Intestinal Mucosa/*cytology
MH  - Models, Biological
MH  - Neoplastic Stem Cells/metabolism
MH  - Stem Cell Niche
MH  - Stem Cells/cytology/*metabolism
EDAT- 2012/05/31 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - 10.1002/wsbm.1176 [doi]
PST - ppublish
SO  - Wiley Interdiscip Rev Syst Biol Med. 2012 Sep-Oct;4(5):475-96. doi: 
      10.1002/wsbm.1176. Epub 2012 May 29.