PMID- 22659496
OWN - NLM
STAT- MEDLINE
DCOM- 20121219
LR  - 20220408
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Print)
IS  - 1084-9521 (Linking)
VI  - 23
IP  - 7
DP  - 2012 Sep
TI  - The YAP and TAZ transcription co-activators: key downstream effectors of the 
      mammalian Hippo pathway.
PG  - 785-93
LID - S1084-9521(12)00105-X [pii]
LID - 10.1016/j.semcdb.2012.05.004 [doi]
AB  - The Hippo signaling pathway was initially defined by genetic studies in 
      Drosophila to regulate tissue growth and organ size [1,2]. This pathway is highly 
      conserved in mammals and dysregulation of the Hippo pathway has been implicated 
      in human cancer. Although the exact extracellular signal that controls the Hippo 
      pathway is currently unknown, compelling evidence supports a critical role of the 
      Hippo pathway in cell contact inhibition, which is a property commonly lost in 
      cancer cells. Many molecules, such as the merlin tumor suppressor protein, have 
      been identified as regulating the activity of the core Hippo pathway components 
      [1,2]. Acting downstream are two key transcription co-activators, YAP and TAZ, 
      which mediate the major gene regulation and biological functions of the Hippo 
      pathway. This article will focus on the physiological function and molecular 
      regulation of YAP/TAZ and its Drosophila homolog Yki.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Hong, Wanjin
AU  - Hong W
AD  - School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, People's 
      Republic of China. mcbhwj@imcb.a-star.edu.sg
FAU - Guan, Kun-Liang
AU  - Guan KL
LA  - eng
GR  - R01 CA132809/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20120529
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mammals
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - *Signal Transduction
MH  - Trans-Activators/*metabolism
MH  - Transcription Factors/metabolism
MH  - Transcription, Genetic
PMC - PMC3459069
MID - NIHMS387810
EDAT- 2012/06/05 06:00
MHDA- 2012/12/20 06:00
PMCR- 2013/09/01
CRDT- 2012/06/05 06:00
PHST- 2012/02/08 00:00 [received]
PHST- 2012/05/16 00:00 [revised]
PHST- 2012/05/22 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/12/20 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - S1084-9521(12)00105-X [pii]
AID - 10.1016/j.semcdb.2012.05.004 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2012 Sep;23(7):785-93. doi: 10.1016/j.semcdb.2012.05.004. 
      Epub 2012 May 29.