PMID- 22669819
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20220408
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Linking)
VI  - 139
IP  - 13
DP  - 2012 Jul
TI  - The Prdm family: expanding roles in stem cells and development.
PG  - 2267-82
LID - 10.1242/dev.070110 [doi]
AB  - Members of the Prdm family are characterized by an N-terminal PR domain that is 
      related to the SET methyltransferase domain, and multiple zinc fingers that 
      mediate sequence-specific DNA binding and protein-protein interactions. Prdm 
      factors either act as direct histone methyltransferases or recruit a suite of 
      histone-modifying enzymes to target promoters. In this way, they function in many 
      developmental contexts to drive and maintain cell state transitions and to modify 
      the activity of developmental signalling pathways. Here, we provide an overview 
      of the structure and function of Prdm family members and discuss the roles played 
      by these proteins in stem cells and throughout development.
FAU - Hohenauer, Tobias
AU  - Hohenauer T
AD  - Disease Mechanism Research Core, RIKEN Brain Science Institute, Wako, Saitama, 
      351-0198, Japan.
FAU - Moore, Adrian W
AU  - Moore AW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Xenopus Proteins)
RN  - 0 (Zebrafish Proteins)
RN  - EC 2.1.1.- (Methyltransferases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Caenorhabditis elegans Proteins/metabolism
MH  - Cell Differentiation/physiology
MH  - DNA-Binding Proteins/*metabolism
MH  - Drosophila Proteins/metabolism
MH  - Embryonic Development/*physiology
MH  - Methyltransferases/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protein Structure, Tertiary
MH  - Signal Transduction/physiology
MH  - Stem Cells/*metabolism
MH  - Xenopus Proteins/metabolism
MH  - Zebrafish Proteins/metabolism
MH  - Zinc Fingers/*physiology
EDAT- 2012/06/07 06:00
MHDA- 2012/08/16 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
AID - 139/13/2267 [pii]
AID - 10.1242/dev.070110 [doi]
PST - ppublish
SO  - Development. 2012 Jul;139(13):2267-82. doi: 10.1242/dev.070110.