PMID- 22677547
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20220408
IS  - 1549-5477 (Electronic)
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 26
IP  - 12
DP  - 2012 Jun 15
TI  - Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the 
      oncogenic activity of YAP.
PG  - 1300-5
LID - 10.1101/gad.192856.112 [doi]
AB  - The Drosophila TEAD ortholog Scalloped is required for Yki-mediated overgrowth 
      but is largely dispensable for normal tissue growth, suggesting that its 
      mammalian counterpart may be exploited for selective inhibition of oncogenic 
      growth driven by YAP hyperactivation. Here we test this hypothesis genetically 
      and pharmacologically. We show that a dominant-negative TEAD molecule does not 
      perturb normal liver growth but potently suppresses hepatomegaly/tumorigenesis 
      resulting from YAP overexpression or Neurofibromin 2 (NF2)/Merlin inactivation. 
      We further identify verteporfin as a small molecule that inhibits TEAD-YAP 
      association and YAP-induced liver overgrowth. These findings provide proof of 
      principle that inhibiting TEAD-YAP interactions is a pharmacologically viable 
      strategy against the YAP oncoprotein.
FAU - Liu-Chittenden, Yi
AU  - Liu-Chittenden Y
AD  - Howard Hughes Medical Institute, Maryland, USA.
FAU - Huang, Bo
AU  - Huang B
FAU - Shim, Joong Sup
AU  - Shim JS
FAU - Chen, Qian
AU  - Chen Q
FAU - Lee, Se-Jin
AU  - Lee SJ
FAU - Anders, Robert A
AU  - Anders RA
FAU - Liu, Jun O
AU  - Liu JO
FAU - Pan, Duojia
AU  - Pan D
LA  - eng
GR  - R01 CA122814/CA/NCI NIH HHS/United States
GR  - R01EY015708/EY/NEI NIH HHS/United States
GR  - R01 AR060636/AR/NIAMS NIH HHS/United States
GR  - R01DK081417/DK/NIDDK NIH HHS/United States
GR  - R01AR060636/AR/NIAMS NIH HHS/United States
GR  - R01 EY015708/EY/NEI NIH HHS/United States
GR  - R01 DK081417/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120607
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Neurofibromin 2)
RN  - 0 (Phosphoproteins)
RN  - 0 (Porphyrins)
RN  - 0 (TEA Domain Transcription Factors)
RN  - 0 (Tead2 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yap1 protein, mouse)
RN  - 0X9PA28K43 (Verteporfin)
SB  - IM
CIN - Genes Dev. 2012 Jun 15;26(12):1263-7. PMID: 22713867
MH  - Adaptor Proteins, Signal Transducing/*genetics/metabolism
MH  - Animals
MH  - Cell Cycle Proteins
MH  - Cell Transformation, Neoplastic/metabolism/*pathology
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Genes, Dominant/genetics
MH  - HEK293 Cells
MH  - Hepatomegaly/metabolism/pathology
MH  - Humans
MH  - Liver/drug effects/metabolism/pathology
MH  - Mice
MH  - Mice, Transgenic
MH  - Multiprotein Complexes/*metabolism
MH  - Neurofibromin 2/metabolism
MH  - Phenotype
MH  - Phosphoproteins/*genetics/metabolism
MH  - Porphyrins/*pharmacology
MH  - Protein Binding/drug effects
MH  - TEA Domain Transcription Factors
MH  - Transcription Factors/*genetics/metabolism
MH  - Verteporfin
MH  - YAP-Signaling Proteins
PMC - PMC3387657
EDAT- 2012/06/09 06:00
MHDA- 2012/08/31 06:00
PMCR- 2012/12/15
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
PHST- 2012/12/15 00:00 [pmc-release]
AID - gad.192856.112 [pii]
AID - 10.1101/gad.192856.112 [doi]
PST - ppublish
SO  - Genes Dev. 2012 Jun 15;26(12):1300-5. doi: 10.1101/gad.192856.112. Epub 2012 Jun 
      7.