PMID- 22682109
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20220309
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 37
IP  - 8
DP  - 2012 Aug
TI  - Eaten alive! Cell death by primary phagocytosis: 'phagoptosis'.
PG  - 325-32
LID - 10.1016/j.tibs.2012.05.002 [doi]
AB  - Phagoptosis, also called primary phagocytosis, is a recently recognised form of 
      cell death caused by phagocytosis of viable cells, resulting in their 
      destruction. It is provoked by exposure of 'eat-me' signals and/or loss of 
      'don't-eat-me' signals by viable cells, causing their phagocytosis by phagocytes. 
      Phagoptosis mediates turnover of erythrocytes, neutrophils and other cells, and 
      thus is quantitatively one of the main forms of cell death in the body. It 
      defends against pathogens and regulates inflammation and immunity. However, 
      recent results indicate that inflamed microglia eat viable brain neurons in 
      models of neurodegeneration, and cancer cells can evade phagocytosis by 
      expressing a 'don't-eat-me' signal, suggesting that too much or too little 
      phagoptosis can contribute to pathology. This review provides an overview of the 
      molecular signals that regulate phagoptosis and the physiological and 
      pathological circumstances in which it has been observed.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Brown, Guy C
AU  - Brown GC
AD  - Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge 
      CB2 1QW, UK. gcb@mole.bio.cam.ac.uk
FAU - Neher, Jonas J
AU  - Neher JJ
LA  - eng
GR  - RG50995/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120607
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (Antigens, Surface)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Antigens, Surface/chemistry
MH  - Cell Death
MH  - Cell Survival
MH  - Erythrocytes/chemistry/pathology
MH  - Humans
MH  - Inflammation/pathology
MH  - Microglia/chemistry/pathology
MH  - Neurodegenerative Diseases/*pathology
MH  - Neurons/chemistry/*pathology
MH  - Phagocytes/chemistry
MH  - *Phagocytosis
MH  - Receptors, Cell Surface/chemistry
MH  - Signal Transduction
EDAT- 2012/06/12 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/03/05 00:00 [received]
PHST- 2012/05/06 00:00 [revised]
PHST- 2012/05/10 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0968-0004(12)00070-9 [pii]
AID - 10.1016/j.tibs.2012.05.002 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2012 Aug;37(8):325-32. doi: 10.1016/j.tibs.2012.05.002. Epub 
      2012 Jun 7.