PMID- 22682243
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20240104
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Linking)
VI  - 149
IP  - 6
DP  - 2012 Jun 8
TI  - Wnt/beta-catenin signaling and disease.
PG  - 1192-205
LID - 10.1016/j.cell.2012.05.012 [doi]
AB  - The WNT signal transduction cascade controls myriad biological phenomena 
      throughout development and adult life of all animals. In parallel, aberrant Wnt 
      signaling underlies a wide range of pathologies in humans. In this Review, we 
      provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its 
      various components contribute to disease, and pose outstanding questions to be 
      addressed in the future.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Clevers, Hans
AU  - Clevers H
AD  - Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands. 
      h.clevers@hubrecht.eu
FAU - Nusse, Roel
AU  - Nusse R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Wnt Proteins)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Animals
MH  - Disease/genetics
MH  - Humans
MH  - Wnt Proteins/*metabolism
MH  - *Wnt Signaling Pathway
MH  - beta Catenin/*metabolism
EDAT- 2012/06/12 06:00
MHDA- 2012/08/16 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/01/09 00:00 [received]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
AID - S0092-8674(12)00586-7 [pii]
AID - 10.1016/j.cell.2012.05.012 [doi]
PST - ppublish
SO  - Cell. 2012 Jun 8;149(6):1192-205. doi: 10.1016/j.cell.2012.05.012.