PMID- 22682515
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20220330
IS  - 1471-499X (Electronic)
IS  - 1471-4914 (Linking)
VI  - 18
IP  - 7
DP  - 2012 Jul
TI  - Cell-penetrating peptides: breaking through to the other side.
PG  - 385-93
LID - 10.1016/j.molmed.2012.04.012 [doi]
AB  - Cell-penetrating peptides (CPPs) have been previously shown to be powerful 
      transport vector tools for the intracellular delivery of a large variety of 
      cargoes through the cell membrane. Intracellular delivery of plasmid DNA (pDNA), 
      oligonucleotides, small interfering RNAs (siRNAs), proteins and peptides, 
      contrast agents, drugs, as well as various nanoparticulate pharmaceutical 
      carriers (e.g., liposomes, micelles) has been demonstrated both in vitro and in 
      vivo. This review focuses on the peptide-based strategy for intracellular 
      delivery of CPP-modified nanocarriers to deliver small molecule drugs or DNA. In 
      addition, we discuss the rationales for the design of 'smart' pharmaceutical 
      nanocarriers in which the cell-penetrating properties are hidden until triggered 
      by exposure to appropriate environmental conditions (e.g., a particular pH, 
      temperature, or enzyme level), applied local microwave, ultrasound, or 
      radiofrequency radiation.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Koren, Erez
AU  - Koren E
AD  - Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern 
      University, 312 Mugar Life Sciences Building, 360 Huntington Avenue, Boston, MA 
      02115, USA.
FAU - Torchilin, Vladimir P
AU  - Torchilin VP
LA  - eng
GR  - R01 CA121838/CA/NCI NIH HHS/United States
GR  - R01 CA128486/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120607
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (Cell-Penetrating Peptides)
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Cell Membrane/metabolism
MH  - Cell-Penetrating Peptides/chemistry/classification/*metabolism
MH  - Drug Carriers/chemistry/metabolism
MH  - Humans
EDAT- 2012/06/12 06:00
MHDA- 2012/10/27 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/02/10 00:00 [received]
PHST- 2012/04/24 00:00 [revised]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - S1471-4914(12)00075-5 [pii]
AID - 10.1016/j.molmed.2012.04.012 [doi]
PST - ppublish
SO  - Trends Mol Med. 2012 Jul;18(7):385-93. doi: 10.1016/j.molmed.2012.04.012. Epub 
      2012 Jun 7.