PMID- 22704512 OWN - NLM STAT- MEDLINE DCOM- 20121011 LR - 20220408 IS - 1875-9777 (Electronic) IS - 1875-9777 (Linking) VI - 10 IP - 6 DP - 2012 Jun 14 TI - Cancer stem cells: current status and evolving complexities. PG - 717-728 LID - S1934-5909(12)00240-8 [pii] LID - 10.1016/j.stem.2012.05.007 [doi] AB - The cancer stem cell (CSC) model has been established as a cellular mechanism that contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent observations, however, have highlighted many complexities and challenges: the CSC phenotype can vary substantially between patients, tumors may harbor multiple phenotypically or genetically distinct CSCs, metastatic CSCs can evolve from primary CSCs, and tumor cells may undergo reversible phenotypic changes. Although the CSC concept will have clinical relevance in specific cases, accumulating evidence suggests that it will be imperative to target all CSC subsets within the tumor to prevent relapse. CI - Copyright (c) 2012 Elsevier Inc. All rights reserved. FAU - Visvader, Jane E AU - Visvader JE AD - VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3050, Australia. Electronic address: visvader@wehi.edu.au. FAU - Lindeman, Geoffrey J AU - Lindeman GJ AD - VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3050, Australia; Department of Medical Oncology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Cell Stem Cell JT - Cell stem cell JID - 101311472 SB - IM MH - Animals MH - Cell Differentiation MH - Cell Proliferation MH - Humans MH - Neoplasms/*pathology MH - Neoplastic Stem Cells/*pathology MH - Phenotype EDAT- 2012/06/19 06:00 MHDA- 2012/10/12 06:00 CRDT- 2012/06/19 06:00 PHST- 2012/06/19 06:00 [entrez] PHST- 2012/06/19 06:00 [pubmed] PHST- 2012/10/12 06:00 [medline] AID - S1934-5909(12)00240-8 [pii] AID - 10.1016/j.stem.2012.05.007 [doi] PST - ppublish SO - Cell Stem Cell. 2012 Jun 14;10(6):717-728. doi: 10.1016/j.stem.2012.05.007.