PMID- 22770212
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20221102
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Linking)
VI  - 150
IP  - 1
DP  - 2012 Jul 6
TI  - Cancer epigenetics: from mechanism to therapy.
PG  - 12-27
LID - 10.1016/j.cell.2012.06.013 [doi]
AB  - The epigenetic regulation of DNA-templated processes has been intensely studied 
      over the last 15 years. DNA methylation, histone modification, nucleosome 
      remodeling, and RNA-mediated targeting regulate many biological processes that 
      are fundamental to the genesis of cancer. Here, we present the basic principles 
      behind these epigenetic pathways and highlight the evidence suggesting that their 
      misregulation can culminate in cancer. This information, along with the promising 
      clinical and preclinical results seen with epigenetic drugs against chromatin 
      regulators, signifies that it is time to embrace the central role of epigenetics 
      in cancer.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Dawson, Mark A
AU  - Dawson MA
AD  - Gurdon Institute and Department of Pathology, University of Cambridge, Tennis 
      Court Road, Cambridge CB2 1QN, UK.
FAU - Kouzarides, Tony
AU  - Kouzarides T
LA  - eng
GR  - 092096/Wellcome Trust/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
SB  - IM
MH  - Chromatin Assembly and Disassembly
MH  - DNA Methylation
MH  - *Epigenesis, Genetic
MH  - Epigenomics
MH  - Gene Expression Regulation, Neoplastic
MH  - Histone Code
MH  - Humans
MH  - Neoplasms/*drug therapy/*genetics/metabolism
EDAT- 2012/07/10 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - S0092-8674(12)00762-3 [pii]
AID - 10.1016/j.cell.2012.06.013 [doi]
PST - ppublish
SO  - Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.