PMID- 22797069
OWN - NLM
STAT- MEDLINE
DCOM- 20130814
LR  - 20161125
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Linking)
VI  - 32
IP  - 24
DP  - 2013 Jun 13
TI  - Elevated PLGF contributes to small-cell lung cancer brain metastasis.
PG  - 2952-62
LID - 10.1038/onc.2012.313 [doi]
AB  - Brain metastasis (BM) is a major cause of mortality in small-cell lung cancer 
      (SCLC) patients; however, the molecular pathway of SCLC BM remains largely 
      unknown because of a lack of investigation. Here we screen the levels of some 
      candidate-soluble factors in the serum of SCLC patients and find that SCLC 
      patients with high levels of placental growth factor (PLGF) are prone to BM. 
      Using in vitro blood-brain barrier model, we show that PLGF derived from SCLC 
      cells triggers vascular endothelial growth factor receptor-1-Rho-extracellular 
      regulated protein kinase 1/2 signaling axis activation, results in disassembly of 
      tight junction in brain endothelial cells and promotes SCLC cell transendothelial 
      migration. Furthermore, the downregulation of PLGF suppresses SCLC cell 
      metastasis to the brain in an experimental BM model. These data suggest that PLGF 
      is a potential signature of SCLC BM and a prospective therapeutic target for SCLC 
      BM.
FAU - Li, B
AU  - Li B
AD  - Department of Developmental Biology, Key Laboratory of Cell Biology, Ministry of 
      Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, 
      China Medical University, Shenyang, China.
FAU - Wang, C
AU  - Wang C
FAU - Zhang, Y
AU  - Zhang Y
FAU - Zhao, X Y
AU  - Zhao XY
FAU - Huang, B
AU  - Huang B
FAU - Wu, P F
AU  - Wu PF
FAU - Li, Q
AU  - Li Q
FAU - Li, H
AU  - Li H
FAU - Liu, Y S
AU  - Liu YS
FAU - Cao, L Y
AU  - Cao LY
FAU - Dai, W M
AU  - Dai WM
FAU - Fang, W G
AU  - Fang WG
FAU - Shang, D S
AU  - Shang DS
FAU - Cao, L
AU  - Cao L
FAU - Zhao, W D
AU  - Zhao WD
FAU - Chen, Y H
AU  - Chen YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120716
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (PGF protein, human)
RN  - 0 (Pgf protein, mouse)
RN  - 0 (Pregnancy Proteins)
RN  - 144589-93-5 (Placenta Growth Factor)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
RN  - EC 2.7.11.1 (rho-Associated Kinases)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Animals
MH  - Brain/pathology
MH  - Brain Neoplasms/*secondary
MH  - Cell Line, Tumor
MH  - Endothelial Cells/pathology
MH  - Enzyme Activation
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*blood/*pathology
MH  - Male
MH  - Mice
MH  - Placenta Growth Factor
MH  - Pregnancy Proteins/*blood
MH  - Signal Transduction
MH  - Small Cell Lung Carcinoma/*blood/*pathology
MH  - Tight Junctions/metabolism/pathology
MH  - Transendothelial and Transepithelial Migration
MH  - Vascular Endothelial Growth Factor Receptor-1/metabolism
MH  - rho-Associated Kinases/metabolism
EDAT- 2012/07/17 06:00
MHDA- 2013/08/15 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/08/15 06:00 [medline]
AID - onc2012313 [pii]
AID - 10.1038/onc.2012.313 [doi]
PST - ppublish
SO  - Oncogene. 2013 Jun 13;32(24):2952-62. doi: 10.1038/onc.2012.313. Epub 2012 Jul 
      16.