PMID- 22895435
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20240104
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Linking)
VI  - 13
IP  - 9
DP  - 2012 Sep
TI  - Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
PG  - 591-600
LID - 10.1038/nrm3416 [doi]
AB  - The physical and mechanical properties of the cellular microenvironment regulate 
      cell shape and can strongly influence cell fate. How mechanical cues are sensed 
      and transduced to regulate gene expression has long remained elusive. Recently, 
      cues from the extracellular matrix, cell adhesion sites, cell shape and the 
      actomyosin cytoskeleton were found to converge on the regulation of the 
      downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ 
      (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie 
      in flies. This convergence may explain how mechanical signals can direct normal 
      and pathological cell behaviour.
FAU - Halder, Georg
AU  - Halder G
AD  - Viaams Instituut voor Biotechnologie Center for the Biology, Katholieke 
      Universiteit Leuven, 3000 Leuven, Belgium.
FAU - Dupont, Sirio
AU  - Dupont S
FAU - Piccolo, Stefano
AU  - Piccolo S
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120816
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Transcriptional Coactivator with PDZ-Binding Motif Proteins)
RN  - 0 (WWTR1 protein, human)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Animals
MH  - Apoptosis
MH  - Cell Adhesion
MH  - Cell Differentiation
MH  - Cell Shape
MH  - Cellular Microenvironment
MH  - Cytoskeleton/*metabolism
MH  - Extracellular Matrix/metabolism
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - *Mechanotransduction, Cellular
MH  - Mesenchymal Stem Cells/metabolism
MH  - Models, Biological
MH  - Nuclear Proteins/*metabolism
MH  - Phosphoproteins/*metabolism
MH  - Stress, Mechanical
MH  - Trans-Activators
MH  - Transcription Factors
MH  - Transcriptional Coactivator with PDZ-Binding Motif Proteins
MH  - YAP-Signaling Proteins
EDAT- 2012/08/17 06:00
MHDA- 2012/10/31 06:00
CRDT- 2012/08/17 06:00
PHST- 2012/08/17 06:00 [entrez]
PHST- 2012/08/17 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - nrm3416 [pii]
AID - 10.1038/nrm3416 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2012 Sep;13(9):591-600. doi: 10.1038/nrm3416. Epub 2012 
      Aug 16.