PMID- 22972936
OWN - NLM
STAT- MEDLINE
DCOM- 20121205
LR  - 20211203
IS  - 1549-5477 (Electronic)
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 26
IP  - 19
DP  - 2012 Oct 1
TI  - Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs).
PG  - 2138-43
LID - 10.1101/gad.197582.112 [doi]
AB  - The Hippo signaling pathway plays a crucial role in tissue growth and 
      tumorigenesis. Core components of the Hippo pathway include the MST1/2 and 
      Lats1/2 kinases. Acting downstream from the Hippo pathway are the YAP/TAZ 
      transcription coactivators, which are inhibited through phosphorylation by Lats. 
      However, upstream signals that regulate the Hippo pathway have not been well 
      delineated. Here we report that stimulation of protease-activated receptors 
      (PARs) activates YAP/TAZ by decreasing phosphorylation and increasing nuclear 
      localization. PAR1 acts through G(12/13) and Rho GTPase to inhibit the Lats1/2 
      kinase. Our observations establish thrombin as a physiological signal for the 
      Hippo pathway and implicate Hippo-YAP as a key downstream signaling branch of PAR 
      activation.
FAU - Mo, Jung-Soon
AU  - Mo JS
AD  - Department of Pharmacology, Moores Cancer Center, University of California at San 
      Diego, La Jolla, California 92093, USA.
FAU - Yu, Fa-Xing
AU  - Yu FX
FAU - Gong, Rui
AU  - Gong R
FAU - Brown, Joan Heller
AU  - Brown JH
FAU - Guan, Kun-Liang
AU  - Guan KL
LA  - eng
GR  - R01 EY022611/EY/NEI NIH HHS/United States
GR  - R01 CA218859/CA/NCI NIH HHS/United States
GR  - R37 HL028143/HL/NHLBI NIH HHS/United States
GR  - P01 HL085577/HL/NHLBI NIH HHS/United States
GR  - R01 GM036927/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120912
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oligopeptides)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Receptors, Proteinase-Activated)
RN  - 0 (Ser-Phe-Phe-Leu-Arg-Asn)
RN  - 0 (Transcription Factors)
RN  - 0 (YY1AP1 protein, human)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (TAFAZZIN protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Actin Cytoskeleton
MH  - Acyltransferases
MH  - Cell Cycle Proteins
MH  - Cell Line, Tumor
MH  - Cell Nucleus/enzymology
MH  - Enzyme Activation/physiology
MH  - Gene Expression Regulation
MH  - Gene Knockdown Techniques
MH  - HEK293 Cells
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Nuclear Proteins/genetics/*metabolism
MH  - Oligopeptides/metabolism
MH  - Phosphorylation
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - Protein Transport
MH  - RNA, Small Interfering/metabolism
MH  - Receptors, Proteinase-Activated/agonists/*metabolism
MH  - Transcription Factors/genetics/*metabolism
PMC - PMC3465735
EDAT- 2012/09/14 06:00
MHDA- 2012/12/10 06:00
PMCR- 2012/10/01
CRDT- 2012/09/14 06:00
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - gad.197582.112 [pii]
AID - 10.1101/gad.197582.112 [doi]
PST - ppublish
SO  - Genes Dev. 2012 Oct 1;26(19):2138-43. doi: 10.1101/gad.197582.112. Epub 2012 Sep 
      12.