PMID- 22993326
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20220408
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 32
IP  - 9
DP  - 2012 Sep
TI  - Correlation of expression of phosphorylated and non-phosphorylated Yes-associated 
      protein with clinicopathological parameters in esophageal squamous cell carcinoma 
      in a Korean population.
PG  - 3835-40
AB  - Yes-associated protein (YAP) is a nuclear downstream effector of the Hippo 
      pathway, a regulator of cell growth. The phosphorylated form of YAP (pYAP), 
      located in the cytoplasm, prevents cellular proliferation by spatially 
      segregating YAP from the nucleus. This study aimed at investigating the 
      relationships of pYAP and YAP with clinicopathological variables in esophageal 
      squamous cell carcinoma (ESCC). Samples of ESCC from 142 patients were studied 
      using immunohistochemistry for YAP, pYAP and Ki-67. In all cases of ESCC, higher 
      nuclear expression of YAP was correlated with Ki-67 expression, tumor diameter, 
      histological grade (1-2 versus 3), and pathological TNM stage (I versus II-IV) in 
      univariate analyses (p=0.036, p=0.025, p=0.021, and p=0.033, respectively). 
      Higher nuclear expression of YAP was associated with worse overall and 
      disease-free survival (p=0.006 and p=0.008, respectively). Multivariate analysis 
      showed higher nuclear expression of YAP to be an independent prognostic marker 
      for overall survival (p=0.034). We observed a trend towards inverse correlation 
      of cytoplasmic pYAP expression and histological grade (1-2 versus 3) (p=0.087). 
      Our results suggest that YAP shifts from the nucleus to the cytoplasm as a 
      consequence of phosphorylation, which occurs in the presence of high tumor cell 
      density in the case of ESCC, and may be a potential indication of histological 
      differentiation. Nuclear expression of YAP is correlated with tumor cell 
      proliferation and is an independent predictor of worse prognosis of ESCC.
FAU - Yeo, Min-Kyung
AU  - Yeo MK
AD  - Department of Pathology, Chungnam National University, Daejeon, Republic of 
      Korea.
FAU - Kim, Seok-Hyung
AU  - Kim SH
FAU - Kim, Jin Man
AU  - Kim JM
FAU - Huang, Song-Mei
AU  - Huang SM
FAU - Kim, Mi-Ran
AU  - Kim MR
FAU - Song, Kyu Sang
AU  - Song KS
FAU - Kim, Kyung-Hee
AU  - Kim KH
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Esophageal Neoplasms/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/biosynthesis
MH  - Male
MH  - Neoplasm Staging
MH  - Nuclear Proteins/biosynthesis/*metabolism
MH  - Phosphoproteins/biosynthesis/*metabolism
MH  - Phosphorylation
MH  - Transcription Factors/biosynthesis/*metabolism
MH  - YAP-Signaling Proteins
EDAT- 2012/09/21 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - 32/9/3835 [pii]
PST - ppublish
SO  - Anticancer Res. 2012 Sep;32(9):3835-40.