PMID- 23001125
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20220410
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 44
IP  - 11
DP  - 2012 Nov
TI  - Recurrent somatic TET2 mutations in normal elderly individuals with clonal 
      hematopoiesis.
PG  - 1179-81
LID - 10.1038/ng.2413 [doi]
AB  - Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem 
      cells and by increased risk of myeloid malignancies. Exome sequencing of three 
      elderly females with clonal hematopoiesis, demonstrated by X-inactivation 
      analysis, identified somatic TET2 mutations. Recurrence testing identified TET2 
      mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 
      mutations were specific to individuals with clonal hematopoiesis without 
      hematological malignancies and were associated with alterations in DNA 
      methylation.
FAU - Busque, Lambert
AU  - Busque L
AD  - Research Centre, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada. 
      lbusque.hmr@ssss.gouv.qc.ca
FAU - Patel, Jay P
AU  - Patel JP
FAU - Figueroa, Maria E
AU  - Figueroa ME
FAU - Vasanthakumar, Aparna
AU  - Vasanthakumar A
FAU - Provost, Sylvie
AU  - Provost S
FAU - Hamilou, Zineb
AU  - Hamilou Z
FAU - Mollica, Luigina
AU  - Mollica L
FAU - Li, Juan
AU  - Li J
FAU - Viale, Agnes
AU  - Viale A
FAU - Heguy, Adriana
AU  - Heguy A
FAU - Hassimi, Maryam
AU  - Hassimi M
FAU - Socci, Nicholas
AU  - Socci N
FAU - Bhatt, Parva K
AU  - Bhatt PK
FAU - Gonen, Mithat
AU  - Gonen M
FAU - Mason, Christopher E
AU  - Mason CE
FAU - Melnick, Ari
AU  - Melnick A
FAU - Godley, Lucy A
AU  - Godley LA
FAU - Brennan, Cameron W
AU  - Brennan CW
FAU - Abdel-Wahab, Omar
AU  - Abdel-Wahab O
FAU - Levine, Ross L
AU  - Levine RL
LA  - eng
GR  - U54 CA143798/CA/NCI NIH HHS/United States
GR  - R01 CA129831/CA/NCI NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - 1R01CA129831-03S1/CA/NCI NIH HHS/United States
GR  - 1R01CA138234-01/CA/NCI NIH HHS/United States
GR  - F32 DK092030/DK/NIDDK NIH HHS/United States
GR  - 1R01CA129831/CA/NCI NIH HHS/United States
GR  - R01 CA138234/CA/NCI NIH HHS/United States
GR  - U54CA143798-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120923
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 6R795CQT4H (5-Methylcytosine)
RN  - EC 1.13.11.- (Dioxygenases)
RN  - EC 1.13.11.- (TET2 protein, human)
SB  - IM
MH  - 5-Methylcytosine/metabolism
MH  - Aging/*genetics
MH  - DNA Methylation/*genetics
MH  - *DNA-Binding Proteins/genetics/metabolism
MH  - Dioxygenases
MH  - Exome
MH  - Female
MH  - Hematopoiesis
MH  - Humans
MH  - *Proto-Oncogene Proteins/genetics/metabolism
MH  - X Chromosome Inactivation
PMC - PMC3483435
MID - NIHMS403965
EDAT- 2012/09/25 06:00
MHDA- 2013/04/05 06:00
PMCR- 2013/05/01
CRDT- 2012/09/25 06:00
PHST- 2012/02/27 00:00 [received]
PHST- 2012/08/28 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - ng.2413 [pii]
AID - 10.1038/ng.2413 [doi]
PST - ppublish
SO  - Nat Genet. 2012 Nov;44(11):1179-81. doi: 10.1038/ng.2413. Epub 2012 Sep 23.