PMID- 23034192
OWN - NLM
STAT- MEDLINE
DCOM- 20121219
LR  - 20220321
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Linking)
VI  - 23
IP  - 7
DP  - 2012 Sep
TI  - Hippo signaling in mammalian stem cells.
PG  - 818-26
LID - S1084-9521(12)00142-5 [pii]
LID - 10.1016/j.semcdb.2012.08.001 [doi]
AB  - Over the past decade, the Hippo signaling cascade has been linked to organ size 
      regulation in mammals. Indeed, modulation of the Hippo pathway can have potent 
      effects on cellular proliferation and/or apoptosis and a deregulation of the 
      pathway often leads to tumor development. Importantly, emerging evidence 
      indicates that the Hippo pathway can modulate its effects on tissue size by the 
      regulation of stem and progenitor cell activity. This role has recently been 
      associated with the central position of the pathway in sensing spatiotemporal or 
      mechanical cues, and translating them into specific cellular outputs. These 
      results provide an attractive model for how the Hippo cascade might sense and 
      transduce cellular 'neighborhood' cues into activation of tissue-specific stem or 
      progenitors cells. A further understanding of this process could allow the 
      development of new therapies for various degenerative diseases and cancers. Here, 
      we review current and emerging data linking Hippo signaling to progenitor cell 
      function.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Tremblay, Annie M
AU  - Tremblay AM
AD  - Stem Cell Program, Children's Hospital, Boston, MA 02115, USA.
FAU - Camargo, Fernando D
AU  - Camargo FD
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20120808
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Mammals
MH  - Organ Specificity
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - *Signal Transduction
MH  - Stem Cells/*metabolism
EDAT- 2012/10/05 06:00
MHDA- 2012/12/20 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/07/24 00:00 [revised]
PHST- 2012/08/02 00:00 [accepted]
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2012/12/20 06:00 [medline]
AID - S1084-9521(12)00142-5 [pii]
AID - 10.1016/j.semcdb.2012.08.001 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2012 Sep;23(7):818-26. doi: 10.1016/j.semcdb.2012.08.001. 
      Epub 2012 Aug 8.